Ondansetron hydrochloride is a selective 5HT3-antagonist approved for the management
of nausea and vomiting induced by cancer chemotherapy and radiotherapy. It is reported
to have a superior side-effect profile compared with metoclopramide, representing an
important advance in the treatment of nausea and vomiting associated with chemotherapy.
Ondansetron hydrochloride is the first specific 5HT3-antagonist to reach the market. It is
also under investigation for a number of other indications, including anxiety and
schizophrenia.
화학적 성질
White or almost white powder.
용도
Ondansetron hydrochloride dihydrate has been used as a 5-HT3 antagonist to attenuate rostro ventromedial medulla (RVM)/cholecystokinin (CCK)-induced mechanical hypersensitivity and to block the effects of trichostatin A (TSA) on 5-HT3 protein.
일반 설명
Ondansetron Hydrochloride acts as a 5HT3 (serotonin) antagonist and is a powerful antiemetic drug. It is widely used for the prevention and treatment of nausea and vomiting related to post-operative states, cancer chemotherapy and radiotherapy, and chronic medical illness. It has been found to exhibit inconsistent bioavailability resulting from its poor aqueous solubility and high first-pass hepatic metabolism. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
생물학적 활성
Selective 5-HT 3 receptor antagonist (K i = 6.16 nM). Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.
