O-크레졸

O-크레졸
O-크레졸 구조식 이미지
카스 번호:
95-48-7
한글명:
O-크레졸
동의어(한글):
O-크레졸;O-크레솔;1-메틸-2-하이드록시벤젠;1-하이드록시-2-메틸벤젠;2-메틸페놀;2-크레졸;2-하이드록시-1-메틸벤젠;2-하이드록시톨루엔;O-메틸페놀;O-옥시톨루엔;O-크레실산;o-하이드록시톨루엔;오쏘-크레솔;크레솔, 오쏘;페놀, 2-메틸-
상품명:
o-Cresol
동의어(영문):
2-METHYLPHENOL;Orthocresol;ortho-cresol;2-Cresol;Phenol,2-methyl-;o-Creso;ORTHO CRESO;2-HYDROXYTOLUENE;O-HYDROXYTOLUENE;1-Methyl-2-hydroxybenzene
CBNumber:
CB4854694
분자식:
C7H8O
포뮬러 무게:
108.14
MOL 파일:
95-48-7.mol
MSDS 파일:
SDS

O-크레졸 속성

녹는점
29-31 °C (lit.)
끓는 점
191 °C (lit.)
밀도
1.048 g/mL at 25 °C
증기 밀도
3.72 (vs air)
증기압
0.3 mm Hg ( 20 °C)
FEMA
3480 | O-CRESOL
굴절률
1.5361
인화점
178 °F
저장 조건
under inert gas
용해도
20g/L
물리적 상태
액체 또는 저융점 고체
산도 계수 (pKa)
10.2(at 25℃)
색상
흰색에서 갈색으로
냄새
디프로필렌 글리콜 중 0.01%. 곰팡내 나는 페놀 플라스틱 약초의 가죽 같은
수소이온지수(pH)
4.8 (20g/l, H2O, 20℃)
폭발한계
1.47%, 148°F
Odor Threshold
0.00028ppm
?? ??
페놀성
수용성
20g/L(20℃)
Merck
14,2579
JECFA Number
691
BRN
506917
Henry's Law Constant
0.34 at 5.25 °C, 0.61 at 10.00 °C, 1.57 at 20.00 °C, 2.33 at 25.00 °C (dynamic equilibrium system- GC, Feigenbrugel et al., 2004a)
노출 한도
NIOSH REL: TWA 2.3 ppm (10 mg/m3), IDLH 250 ppm; OSHA PEL: TWA 5 ppm (22 mg/m3); ACGIH TLV: TWA for all isomers 5 ppm (adopted).
Dielectric constant
5.8(-5℃)
안정성
안정적이지만 가볍고 공기에 민감합니다. 타기 쉬운. 산화제, 염기와 호환되지 않습니다.
InChIKey
QWVGKYWNOKOFNN-UHFFFAOYSA-N
LogP
1.95 at 20℃
CAS 데이터베이스
95-48-7(CAS DataBase Reference)
NIST
Phenol, 2-methyl-(95-48-7)
EPA
o-Cresol (95-48-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T
위험 카페고리 넘버 24/25-34-39/23/24/25-23/24/25
안전지침서 36/37/39-45-36/37
OEB B
OEL TWA: 2.3 ppm (10 mg/m3)
유엔번호(UN No.) UN 3455 6.1/PG 2
WGK 독일 1
RTECS 번호 GO6300000
F 고인화성물질 8-23
자연 발화 온도 555 °C
TSCA Yes
위험 등급 6.1
포장분류 II
HS 번호 29071200
유해 물질 데이터 95-48-7(Hazardous Substances Data)
독성 LD50 orally in rats: 1.35 g/kg (Deichmann, Witherup)
IDLA 250 ppm
기존화학 물질 KE-24792
유해화학물질 필터링 97-1-268
함량 및 규제정보 물질구분: 유독물질; 혼합물(제품)함량정보: 크레졸 및 이를 5% 이상 함유한 혼합물
그림문자(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H411 장기적 영향에 의해 수생생물에 유독함 수생 환경유해성 물질 - 만성 구분 2
예방조치문구:
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
2
3 0

O-크레졸 MSDS


2-Hydroxytoluene

O-크레졸 C화학적 특성, 용도, 생산

화학적 성질

o-Cresol has a musty, phenolic aftertaste.

물리적 성질

Colorless solid or liquid with a phenolic odor; darkens on exposure to air. An odor threshold concentration of 0.28 ppbv was reported by Nagata and Takeuchi (1990).

출처

Reported in Acacial farnesiana, ylang-ylang oil (probably as p-cresyl acetate), jasmine absolute, orange oil from leaves, the essence from flowers of Lilium candidum, anise seed oil, the essence of Artemisia santolinoflia, and some sea algae. Also reported found in asparagus, peppermint oil, cheddar cheese, provolone cheese, butter, milk, lean fish, boiled egg, smoked pork, rum, Scotch whiskey, red wine, white wine, coffee and mango.Reported found in cinnamon, coffee, Oriental tobacco, rum, sherry, tea, tomato and whiskey.

용도

o-Cresol is used as a disinfectant and solvent. Lysol disinfectant is a 50% (v/v) mixed-cresol isomer in a soap emulsion formed on mixing with water. Besides disinfection products at solutions of 1–5%, the cresols are used as degreasing compounds, paintbrush cleaners, and additives in lubricating oils. Cresols were previously widely used for disinfection of poultry houses, but this use was discontinued because of their toxicity; they cause respiratory problems and abdominal edema in young chicks. o-Cresol has been used in synthetic resins, explosives, petroleum, photographic, paint, and agricultural industries.

정의

ChEBI: A cresol that is phenol substituted by a methyl group at position 2. It is a minor urinary metabolite of toluene.

생산 방법

Approximately 60% of o-cresol is obtained from coal-tar and crude oil by using classical techniques such as distillation, stripping, and liquid–liquid extraction. The remaining 40% is obtained synthetically by the alkylation of phenol with methanol. The cresols (cresylic acids) are methyl phenols and generally appear as a mixture of isomers. o-Cresol is a 2-methyl derivative of phenol and is prepared from o-toluic acid or obtained from coal tar or petroleum. Crude cresol is obtained by distilling “gray phenic acid” at a temperature of ≈180–201°C. o-Cresol may be separated from the crude or purified mixture by repeated fractional distillation in vacuo. It can also be prepared synthetically by diazotization of the specific toluidine or by fusion of the corresponding toluenesulfonic acid with sodium hydroxide.

일반 설명

Colorless or yellow to brown-yellow or pinkish colored liquid with a phenol-like odor. Toxic by ingestion and/or skin absorption. May have a flash point between 100 and 199°F. Causes burns to skin, eyes and mucous membranes. Insoluble in water.

공기와 물의 반응

Sensitive to light and air. Insoluble in water.

반응 프로필

o-Cresol is incompatible with oxidizing agents and bases. Mixing o-Cresol with chlorosulfonic acid, nitric acid and oleum in a closed contained caused the temperature and pressure to increase.

위험도

Questionable carcinogen.

건강위험

The chemical is rated as a very toxic compound with a probable oral lethal dose in humans of 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 70 kg (150 lb.) person. It is a strong dermal irritant and frequently causes dermatitis. Serious or fatal poisoning may result if large areas of skin are wet with cresol, o- and the substance is not removed immediately. Ingestion of even a small amount may cause paralysis and coma. It is corrosive to body tissues, with toxicity similar to phenol.

화재위험

Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. o-Cresol may burn but does not ignite readily. Container may explode in heat of fire. Slight explosion and fire hazard in the form of vapor when exposed to heat or flame. When heated to decomposition, o-Cresol emits highly toxic fumes. Reacts violently with nitric acid, oleum, and chlorosulfonic acid. Hazardous polymerization may not occur.

Safety Profile

Poison by ingestion, inhalation, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by skin contact. A severe eye and skin irritant. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. Flammable when exposed to heat, flame, or oxidants. To fight fire, water may be used to blanket fire; foam, fog, mist, dry chemical. See also other cresol entries and PHENOL.

잠재적 노출

Cresol is used as a disinfectant and fumigant; as an ore flotation agent, and as an intermediate in the manufacture of chemicals, dyes, plastics, and antioxidants. A mixture of isomers is generally used; the concentrations of the components are determined by the source of the cresol.

운송 방법

UN2076 Cresols, liquid, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. UN3455 Cresols, solid, Hazard class: 6.1; Labels: 6.1- Poisonous materials, 8-Corrosive material.

Purification Methods

It can be freed from m-and p-isomers by repeated fractional distillation, It crystallises from *benzene by addition of pet ether. It has been fractionallly crystallised by partial freezing of its melt. The 3,5-dinitrobenzoate (prepared with 3,5-dinitrobenzoyl chloride in dry pyridine, and recrystallised from EtOH or aqueous Me2CO) has m 138o. [Beilstein 6 IV 1940.]

비 호환성

Vapors may form explosive mixture with air. Incompatible with strong acids; oxidizers, alkalies, aliphatic amines; amides, chlorosulfonic acid; oleum. Decomposes on heating, producing strong acids and bases, causing fire and explosion hazard. Liquid attacks some plastics and rubber. Attacks many metals.

폐기물 처리

Wastewaters may be subjected to biological treatment. Concentrations may be further reduced by ozone treatment. High concentration wastes may be destroyed in special waste incinerators.

O-크레졸 준비 용품 및 원자재

원자재

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