트로파릴

트로파릴
트로파릴 구조식 이미지
카스 번호:
74163-84-1
한글명:
트로파릴
동의어(한글):
트로파릴
상품명:
Troparil
동의어(영문):
Β-CPT;B-CPT;Troparil;Topalate;Troparil Β-CPT;Troparil Whatsapp;Troparil Impurity;Troparil USP/EP/BP;high purity,Troparil;2-beta-Methoxycarbonyl
CBNumber:
CB51095921
분자식:
C16H21NO2
포뮬러 무게:
259.34
MOL 파일:
74163-84-1.mol

트로파릴 속성

끓는 점
350.2±42.0 °C(Predicted)
밀도
1.099±0.06 g/cm3(Predicted)
산도 계수 (pKa)
9.95±0.60(Predicted)
InChI
InChI=1/C16H21NO2/c1-17-12-8-9-14(17)15(16(18)19-2)13(10-12)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14+,15-/s3
InChIKey
OMBOXYLBBHNWHL-YRABYYAXNA-N
SMILES
[C@@]12([H])N(C)[C@@]([H])(CC1)C[C@H](C1=CC=CC=C1)[C@@H]2C(OC)=O |&1:0,4,9,16,r|

안전

트로파릴 C화학적 특성, 용도, 생산

개요

Troparil is a phenyltropane-based dopamine reuptake inhibitor that is derived from methylecgonidine. It is a stimulant drug used in scientific research. The most commonly used form of troparil is the tartrate salt, but the hydrochloride and naphthalenedisulfonate salts are also available, as well as the free base.

용도

Troparil is used in scientific research into the dopamine reuptake transporter. 3H-radiolabelled forms of troparil have been used in humans and animals to map the distribution of dopamine transporters in the brain. It is also used for animal research into stimulant drugs as an alternative to cocaine which produces similar effects, but avoids the stringent licensing requirements for the use of cocaine itself.

Pharmacokinetics

Troparil is a few times more potent than cocaine as a dopamine reuptake inhibitor, but is less potent as a serotonin reuptake inhibitor, and has a duration spanning a few times longer, since the phenyl ring is directly connected to the tropane ring through a non-hydrolyzable carbon-carbon bond. The lack of an ester linkage removes the local anesthetic action from the drug, so troparil is a pure stimulant. This change in activity also makes troparil slightly less cardiotoxic than cocaine.

트로파릴 준비 용품 및 원자재

원자재

준비 용품


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