모다피닐 C화학적 특성, 용도, 생산
개요
Modafinil, a centrally active α
1-adrenergic agonist, was marketed in France as a
psychostimulant for the treatment of narcolepsy and idiopathic hypersomnia
including Gelineau's syndrome. In monkeys, modafinil was found to induce potent
behavioral stimulation and awakening without stereotyped behavior. In narcoleptic
patients, modafinil reduces the daily number of sleep attacks significantly and
markedly improves performance. The mechanism of action for its locomotor effects
was reported to be due to the stimulation of the central α
1-adrenergic system,
opposite to amphetamine and methylphenidate, which act mainly by dopaminergic
mechanisms. Modafinil has been reported to exhibit minimal peripheral side effects
at therapeutic doses and appears to have low abuse potential. The use of modafinil
in the treatment of cerebral infarction and ischemia has been claimed.
화학적 성질
Crystalline Solid
용도
Modafinil is an α-1-adrenergic agonist. Modafinil is a CNS stimulant; psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease.
일반 설명
Modafinil (Provigil) has overall wakefulness-promotingproperties similar to those of central sympathomimetics. It isconsidered an atypical α1-norepinephrine (NE) receptorstimulant and is used to treat daytime sleepiness in narcolepsypatients. Adverse reactions at therapeutic doses arereportedly not severe and may include nervousness, anxiety,and insomnia. Modafinil is used by oral administration.
생물학적 활성
Psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
모다피닐 준비 용품 및 원자재
원자재
준비 용품
