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7,8-Dihydroxyflavone

7,8-Dihydroxyflavone 구조식 이미지

카스 번호:: 38183-03-8

상품명:: 7,8-Dihydroxyflavone

동의어(영문):: 7,8-DHF;7,8-Dihydroxyflavone hydrate;7,8-dihydroxy-2-phenyl-4-benzopyrone;7,8-DIHYDROXY;7,8-Di-OH flavone;8-Dihydroxyflavone;TIMTEC-BB SBB000930;7,8-DIHYDROXYFLAVONE;DIHYDROXYFLAVONE, 7,8-;7,8-dihydroxy Flavones

CBNumber:: CB5478886

분자식:: C15H10O4

포뮬러 무게:: 254.24

MOL 파일:: 38183-03-8.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 290

7,8-Dihydroxyflavone 속성

녹는점: 243-246°C

끓는 점: 494.4±45.0 °C(Predicted)

밀도: 1.443±0.06 g/cm3(Predicted)

FEMA: 4830 | 7,8-DIHYDROXYFLAVONE

저장 조건: Inert atmosphere,Room Temperature

용해도: DMSO: 가용성24mg/mL

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 6.86±0.40(Predicted)

색상: 노란색 또는 황갈색

안정성: 제공된 대로 구매일로부터 1년 동안 안정적입니다. 습기로부터 보호하십시오. DMSO 또는 에탄올 용액은 -20°C에서 최대 1주일 동안 보관할 수 있습니다.

InChI: InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H

InChIKey: COCYGNDCWFKTMF-UHFFFAOYSA-N

SMILES: C1(C2=CC=CC=C2)OC2=C(O)C(O)=CC=C2C(=O)C=1

LogP: 2.760 (est)

CAS 데이터베이스: 38183-03-8(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn
위험 카페고리 넘버	22
안전지침서	24/25
WGK 독일	3
RTECS 번호	DJ3004000
HS 번호	2932990090

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

NFPA 704

	1
0		0

7,8-Dihydroxyflavone C화학적 특성, 용도, 생산

개요

7,8-Dihydroxyflavone(7,8-DHF) is a naturally occurring flavone found in the tree Godmania aesculifolia. It is a selective tyrosine kinase receptor B(TrkB) agonist that has neurotrophic effects in various neurological diseases such as stroke and Parkinson's disease. 7,8-Dihydroxyflavone binds to the TrkB receptors in a similar way to BDNF, or brain derived neurotrophic factor. When the TrkB receptor is activated, neuroprotective and neurogenetive effects occur in neurons, which tend to affect the dendrites. Dendrites are what reach out from the neurons into the synapse to participate in signaling with other neurons. 7,8-DHF has been shown to promote the growth of these dendrites, and to help restore communication between neurons in animal models.

화학적 성질

White crystalline powder or Yellow Solid, soluble in methanol, ethanol, DMSO and other organic solvents, from the dried root of Pulsatilla chinensis (Bge.) Regel.

용도

7,8-Dihydroxyflavone is disubstituted flavone that acts as a small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to reverse memory deficits and BACE1 elevation in a mouse model of Alzheimer''s disease. 7,8-Dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as Rett syndrome and PTSD. It has recently been shown to counteract the inhibition of NMDA receptor caused by lead poisoning and confer protective effects in live rats.

생물학적 활성

7,8-Dihydroxyflavone (7,8-DHF) is a monophenolic flavone with diverse effects. It acts as an agonist of the neurotrophic tyrosine kinase receptor TrkB (Kd = 320 nM), protecting neurons that express TrkB from apoptosis. 7,8-DHF is neuroprotective in an animal model of Parkinson’s disease. It supports emotional learning in mice and reverses memory deficits in a mouse model of Alzheimer’s disease. It also improves motor function and extends survival in an animal model of Huntington’s disease. 7,8-DHF inhibits the cytochrome P450 aromatase (IC50 = 10 μM) and, in this way, alters estrogen metabolism. It also has antioxidant action that increases intracellular glutathione synthesis and scavenges reactive oxygen species.

7,8-Dihydroxyflavone 준비 용품 및 원자재

원자재

4H-1-Benzopyran-4-one, 2-phenyl-7,8-bis(phenylmethoxy)- 4H-1-Benzopyran-4-one, 7,8-bis(benzoyloxy)-2-phenyl- Ethanone, 1-[2,3,4-tris(phenylmethoxy)phenyl]- Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]- 7,8-디메톡시플라본 2'-HYDROXY-3',4'-DIMETHOXYACETOPHENONE 갈라세토페논 7-HYDROXYFLAVONE 피로갈롤 벤조 무수물 염화벤조일

준비 용품

7,8-Dihydroxyflavone 공급 업체

글로벌( 290)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Wuhan Nutra Biotechnology Co.,Ltd	+8617786394783	nutrabiotech@outlook.com	China	300	58
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	market02@senwayer.com	China	885	58
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd	+86-02223869539 +86-15560057295	trade.kilopharma@foxmail.com	China	27	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12468	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	6011	58
Shanghai Qyubiotech Co., Ltd.	+86-086-021-37596619 +8618019359838	info@qyubiotech.com	China	300	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	Sara@xmwonderfulbio.com	China	305	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	270	58
ARCTIC EXPORTS INC	+1-3026880818 +1-3026880818	ARCTICEXPORTSINC@GMAIL.COM	Canada	68	58

7,8-Dihydroxyflavone 관련 검색:

크리신 탄게레틴 플라본 바이칼린 11-a-Hydroxy canrenone methyl ester (7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester 3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE 3',4',7,8-TETRAMETHOXYFLAVONE 3,7,3',4'-TETRAMETHYLGOSSYPETIN 7,8-Dihydroxyflavone GOSSYPIN 3,7-Bis[(6-deoxy-α-L-mannopyranosyl)oxy]-4',5-dihydroxyflavone 3,6-DIHYDROXYFLAVONE 4',5-DIHYDROXYFLAVONE 3',4'-DIHYDROXYFLAVONE 3,4',6,7-Tetramethoxy-3',5-dihydroxyflavone 4',3-DIHYDROXYFLAVONE,3,4'-DIHYDROXYFLAVONE 3,2'-DIHYDROXYFLAVONE