알비글루타이드

알비글루타이드
알비글루타이드 구조식 이미지
카스 번호:
782500-75-8
한글명:
알비글루타이드
동의어(한글):
알비글루타이드
상품명:
Albiglutide
동의어(영문):
Albugon;Gsk 716155;albiglutide;Naliglutide;Unii-5E7U48495e;Albiglutide Fragment;Albiglutide(Acetate);Albiglutide USP/EP/BP;7-36-Glucagon-like peptide I (8-glycine) (human), fusion protein with 7-36-glucagon-like peptide I (8-glycine) (human) fusion protein with serum;7-36-Glucagon-likepeptide I [8-glycine] (huMan), fusion protein with 7-36-glucagon-like peptide I[8-glycine] (huMan) fusion protein with seruM albuMin (huMan)
CBNumber:
CB61518490
분자식:
C148H223N39O46
포뮬러 무게:
3284.58792
MOL 파일:
782500-75-8.mol

알비글루타이드 속성

저장 조건
Store at -20°C
수용성
Water: 100 mg/mL (30.45 mM);
InChIKey
OGWAVGNOAMXIIM-VTAHJYCESA-N

안전

유해 물질 데이터 782500-75-8(Hazardous Substances Data)

알비글루타이드 C화학적 특성, 용도, 생산

일반 설명

Albiglutide (also known as naliglutide, GSK 716155) isa sequential dimer of GLP-1(7–36)(Ala8→Gly) covalentlylinked to modified human serum albumin (i.e., it is a “fusionprotein” with modified HSA). This molecule is currentlywell into phase III clinical trials. Although albiglutide,if marketed (Syncria, GlaxoSmithKline), will—likeexenatide—be administered by injection, the half-life andduration of 6 to 7 days would allow for weekly administration.

효소 저해제

This GLP-1 agonist and anti-diabetic drug (MW = 72.9 kDa; CAS 782500- 75-8), marketed as Eperzan? and Tanzeum?, by GlaxoSmithKline (GSK) is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide has a half-life of 4-7 days, commending it for biweekly or weekly administration in the treatment of Type 2 diabetes. The half-life is considerably longer than exenatide (Byetta?) and liraglutide (Victoza?).

알비글루타이드 준비 용품 및 원자재

원자재

준비 용품


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