유게놀
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유게놀 속성
- 녹는점
- -12--10 °C (lit.)
- 끓는 점
- 254 °C (lit.)
- 밀도
- 1.067 g/mL at 25 °C (lit.)
- 증기압
- <0.1 hPa (25 °C)
- FEMA
- 2467 | EUGENOL
- 굴절률
- n
20/D 1.541(lit.)
- 인화점
- >230 °F
- 저장 조건
- 2-8°C
- 용해도
- 2.46g/L
- 물리적 상태
- 액체
- 산도 계수 (pKa)
- pKa 9.8 (Uncertain)
- 색상
- 맑은 연한 노란색에서 노란색까지
- 냄새
- 디프로필렌 글리콜 중 10.00%. 달콤하고 매콤한 정향 우디
- ?? ??
- 매운
- 수용성
- 약간 용해됨
- 감도
- Air Sensitive
- Merck
- 14,3898
- JECFA Number
- 1529
- BRN
- 1366759
- Dielectric constant
- 6.1（18℃）
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
- InChIKey
- RRAFCDWBNXTKKO-UHFFFAOYSA-N
- LogP
- 1.83 at 30℃
- CAS 데이터베이스
- 97-53-0(CAS DataBase Reference)
- IARC
- 3 (Vol. 36, Sup 7) 1987
- NIST
- Eugenol(97-53-0)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38-42/43-38-40-43-36/38 | ||
| 안전지침서 | 26-36-24/25-23-36/37 | ||
| 유엔번호(UN No.) | UN1230 - class 3 - PG 2 - Methanol, solution | ||
| WGK 독일 | 1 | ||
| RTECS 번호 | SJ4375000 | ||
| F 고인화성물질 | 10-23 | ||
| TSCA | Yes | ||
| HS 번호 | 29095090 | ||
| 유해 물질 데이터 | 97-53-0(Hazardous Substances Data) | ||
| 독성 | LD50 in rats, mice (mg/kg): 2680, 3000 orally (Hagan) | ||
| 기존화학 물질 | KE-23385 |
유게놀 C화학적 특성, 용도, 생산
개요
무색에서 엷은 노랑색에 이르는 아로마 유액이며 특정한 방향유로부터, 특히 클로브 오일, 육두구, 계피, 바질, 월계수 잎으로부터 추출한다.개요
유제놀, 유게놀, 오이게놀은 페닐프로펜의 액체이다. 유제놀은 페닐프로파노이드계 화합물에 속한다. 무색에서 엷은 노랑색에 이르는 아로마 유액이며 특정한 방향유로부터, 특히 클로브 오일, 육두구, 계피, 바질, 월계수 잎으로부터 추출한다. 클로드 버드 오일의 80~90% 농축물, 클로브 잎 오일의 82~88%의 농축물에 존재한다.독성
유제놀은 간독성이 있으며 이는 간에 위해를 줄 수 있음을 의미한다.과다 복용은 가능하지만 혈변에서부터 경련, 설사, 구역질, 무의식, 어지럼증, 급속한 심박에 이르기까지 다양한 증상을 일으킬 수 있다.순도시험
(1) 비중 : 이 품목의 비중은 1.064～1.070이어야 한다.
(2) 굴절률 : 이 품목의 굴절률 
은 1.540～1.542이어야 한다.
(3) 용상 : 이 품목 2mL를 70% 에탄올 4mL에 녹일 때, 그 액은 징명하여야 한다.
확인시험
(1) 이 품목 5방울을 물 10mL에 녹여 염화제이철시액 3방울을 가하면 청록색을 나타낸다.
(2) 이 품목 0.5g에 피크린산 0.1g, 아세톤 1mL 및 석유에테르 9mL를 넣어 온탕 중에서 피크린산의 결정이 녹을 때까지 가온하면 그 액은 등황색을 나타낸다.
정량법
이 품목은 향료시험법 중 페놀류함량측정법에 따라 시험한다. 다만, 30분간 방치하는 대신에 30분간 수욕 중에서 가열한 다음 실온까지 식힌다.
개요
Sensitization to eugenol mainly occurs in those in dental professions. Eugenol is contained in the "fragrance mix".화학적 성질
Eugenol is the main component of several essential oils; clove leaf oil and cinnamon leaf oilmay contain>90%.Eugenol occurs in small amounts in many other essential oils. It is a colorless to slightly yellow liquid with a spicy, clove odor.Catalytic hydrogenation (e.g., in the presence of noble metal catalysts) yields dihydroeugenol. Isoeugenol is obtained fromeugenol by shifting the double bond. Esterification and etherification of the hydroxy group of eugenol yield valuable fragrance and flavor materials (e.g., eugenol acetate and eugenol methyl ether).
출처
Reported found as a constituent in several volatile oils: clove oil, laurel and cinnamon leaf oil. Smaller amounts of eugenol are also present in the oil of camphor, Java citronella, California laurel and acacia flowers; remarkable amounts of eugenol are found in Ocimum sanctum (70%) and Ocimum gratissimum (60%). Eugenol is also found in the oil from violet flowers (21%); in some plants, eugenol probably occurs as glucoside. Reported found in apricot, citrus oils, raspberry, strawberry, tomato, anise, cinnamon (leaf, bark and roots), clove bud and stem, nutmeg, mace, pepper, smoked fish, beer, whiskey, grape wines, cocoa, mango, tarragon, laurel, myrtle leaf, and pimento berry and leaf.용도
Eugenol is a dental compound which shows cytotoxicity to human oral squamous cell carcinoma and oral cells. When glucosylated, this compound exhibits anti-inflammatory activity.제조 방법
Since sufficient eugenol can be isolated from cheap essential oils, synthesis is not industrially important. Eugenol is still preferentially isolated from clove leaf and cinnamon leaf oil (e.g., by extraction with sodium hydroxide solution). Nonphenolic materials are then removed by steam distillation. After the alkaline solution is acidified at low temperature, pure eugenol is obtained by distillation.정의
ChEBI: A phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group.일반 설명
Clear colorless pale yellow or amber-colored liquid. Odor of cloves. Spicy pungent taste.공기와 물의 반응
Darkens and thickens on exposure to air. Also darkens with age. Eugenol may decompose on exposure to light. Insoluble in water.반응 프로필
Eugenol is incompatible with strong oxidizers. This includes ferric chloride and potassium permanganate. Eugenol reacts with strong alkalis. Eugenol is incompatible with iron and zinc.위험도
Questionable carcinogen.화재위험
Eugenol is combustible.색상 색인 번호
Eugenol is a fragrance allergen obtained from many natural sources. Occupational sensitization to eugenol may occur in dental profession workers. Eugenol is contained in “fragrance mix” and has to be listed by name in cosmetics within the EU.Clinical Use
4-Allyl-2-methoxyphenol is obtained primarily from cloveoil. It is a pale-yellow liquid with a strong aroma of clovesand a pungent taste. Eugenol is only slightly soluble in waterbut is miscible with alcohol and other organic solvents.Eugenol possesses both local anesthetic and antiseptic activityand can be directly applied on a piece of cotton to relievetoothaches. Eugenol is also used in mouthwashes because ofits antiseptic property and pleasant taste. The phenol coefficientof eugenol is 14.4.Anticancer Research
This compound was tested on a model of skin tumor induced by DMBA croton oilin Swiss mice. The eugenol affects the cellular proliferation by increasing apoptosiscellular death. There is evidence for a downregulation of c-myc, H-ras, and Bcl-2expression and an upregulation of p53, Bax, and active caspase-3 (Grondona et al.2014).Safety Profile
Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. Human mutation data reported. A human skin irritant. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALLYL COMPOUNDS.신진 대사
No absorption of eugenol occurred within 2hr of application to the intact shaved skin of mice (Meyer & Meyer, 1959). Following ip injec tion of [14C]eugenol into rats, radioactivity was dis tributed in various organs and the presence of 14CO2 in the expired air indicated the demethylation of eugenol (Weinberg, Rabinowitz, Zanger & Gennaro, 1972). Over 70% of an oral dose of eugenol was excreted in the urine of rabbits (Schr?der & Vollmer, 1932).Purification Methods
Fractional distillation of eugenol gives a pale yellow liquid which darkens and thickens on exposure to air. It should be stored under N2 at -20o. [Waterman & Priedster Recl Trav Chim Pays-Bas 48 1272 1929, Beilstein 6 H 961, 6 IV 6337.]유게놀 준비 용품 및 원자재
원자재
Cassia Aurantium P.E Catechins 8% HPLC
Dry acetone
Eucalyptus Citriodara Oil
과이아콜
오시멘
바질오일
아세트산나트륨, 트리수화물
라우루스노빌리스의월계수오일
Metal copper
보라색잎앱솔루트
탄산 칼륨
리나롤
이산화탄소
CINNAMON LEAVES OIL
브롬화알릴
정향유
캠포 기름
알릴 에테르
염화알릴
준비 용품
유게놀 공급 업체
글로벌( 778)공급 업체
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