세프티부텐
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세프티부텐 속성
- 끓는 점
- 966℃
- 밀도
- 1.75±0.1 g/cm3(Predicted)
- RTECS 번호
- XI0367220
- 인화점
- >110°(230°F)
- 저장 조건
- Keep in dark place,Sealed in dry,2-8°C
- 용해도
- 수용액에 용해됩니다. DMSO에도 용해됨
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 2.99±0.50(Predicted)
- 색상
- 흰색에서 베이지색
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
WGK 독일 | 3 |
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그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Danger | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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세프티부텐 C화학적 특성, 용도, 생산
개요
Ceftibuten is a new, once daily, orally active cephalosporin introduced as a treatment of Gram-negative bacteria-related urinarylrespiratory tract and gynecological infections. In vitro studies of 359 strains of Gram-negative bacteria demonstrated that ceftibuten was superior to cefaclor and as active or slightly more active than cefixime and cefteram.용도
anorexic, antidepressant, inhibitor of 5HT, norepinephrine & dopamine uptake정의
ChEBI: A third-generation cephalosporin antibiotic with a [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino substituent at the 7 position of the cephem skeleton. An orally-administered agent, ceftibuten is used as the dihydrate to tre t urinary-tract and respiratory-tract infections.Antimicrobial activity
A semisynthetic cephalosporin formulated as the dihydrate for oral administration.It exhibits good activity against many Gram-negative bacilli, but its activity against Gram-positive cocci is very poor. It is stable to hydrolysis by the common plasmid-mediated β-lactamases, but not derepressed chromosomal enzymes .
It is rapidly and almost completely absorbed by mouth and is excreted in the urine with a half-life of 1.5–3 h. An oral dose of 400 mg achieves a peak plasma concentration of around 15 mg/L. Binding to plasma proteins is 65–77%.
Side effects mostly consist of mild gastrointestinal symptoms and mild liver function test changes. Clinical trials have mainly been conducted in urinary tract and respiratory tract infections which, despite the poor in-vitro activity against Str. pneumoniae, have shown ceftibuten to be as efficacious as comparator agents.
일반 설명
Chemical structure: ?-lactamPharmacokinetics
Ceftibuten is highly (75–90%) absorbed on oral administration, but this is decreased significantly by food. Being lipophilic and acidic, it is significantly (65%) serum protein bound. Some isomerization of the geometry of the olefinic linkage appears to take place in vivo before excretion.Clinical Use
Ceftibuten (Cedax) is a recently introduced, chemicallynovel analog of the oximino cephalosporins in which anolefinic methylene group (C=CHCH2-) with Z stereochemistryhas replaced the syn oximino (CBNO-) group.This isosteric replacement yields a compound that retainsresistance to hydrolysis catalyzed by many β-lactamases,has enhanced chemical stability, and is orally active. Oralabsorption is rapid and nearly complete. It has the highestoral bioavailability of the third-generation cephalosporins.Ceftibuten is excreted largely unchanged in the urine andhas a half-life of about 2.5 hours. Plasma protein binding ofthis cephalosporin is estimated to be 63%.
Ceftibuten possesses excellent potency against mostmembers of the Enterobacteriaceae family, H. influenzae,Neisseria spp., and M. catarrhalis. It is not active against S.aureus or P. aeruginosa and exhibits modest antistreptococcal activity. Ceftibuten is recommended in the managementof community-acquired respiratory tract, urinary tract, andgynecological infections.
세프티부텐 준비 용품 및 원자재
원자재
자일렌
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite
아니졸
트리플루오로아세트 산
Methylmorpholine
염화알루미늄
테트라하이드로푸란
포름산에틸
준비 용품
세프티부텐 공급 업체
글로벌( 197)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 |
faith@widelychemical.com | CHINA | 742 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9126 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 27945 | 58 |
AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; |
info@afinechem.com | China | 15377 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5999 | 58 |
세프티부텐 관련 검색:
세프트리아존 나트륨 트리스에스퀴수화물 글리신 베타인 세프라딘 세파렉신
ceftibuten sidechain
Cefdinir
Cefixime
ALTRENOGEST
Cefpiramide acid
CeftazidiMe
ceftibuten dihydrate
7-Amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester
Cefprozil hydrate
trans-Ceftibuten
2-(2-AMINOTHIAZOL-4-YL)ETHYLAMINE
2-(2-AMINO-THIAZOL-4-YL)-ACETAMIDE
4-Thiazoleacetamide