QUINACRINE DIHYDROCHLORIDE
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QUINACRINE DIHYDROCHLORIDE 속성
- 녹는점
- 249-251℃ (Decomposition)
- 밀도
- 1.2962 (rough estimate)
- 굴절률
- 1.6300 (estimate)
- 저장 조건
- +15C to +30C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨, 초음파 처리), 물(약간 용해됨)
- 물리적 상태
- 노란색 고체
- 산도 계수 (pKa)
- pKa -6.3(H2O t undefined I not reported but low) (Uncertain)
- 색상
- 밝은 노란색에서 노란색까지
- 수소이온지수(pH)
- 3.0～5.0 (20g/l, 25℃)
- 수용성
- Water: 33.33 mg/mL (70.48 mM)
- Merck
- 14,8044
- BRN
- 4834013
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38 | ||
| 안전지침서 | 36/37/39 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | AR7875000 | ||
| 독성 | LD50 oral in rabbit: 433mg/kg |
| 그림문자(GHS): |
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| 신호 어: | Warning | ||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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QUINACRINE DIHYDROCHLORIDE C화학적 특성, 용도, 생산
화학적 성질
yellow crystals or powder용도
Quinacrine dihydrochloride has been used:- in its uptake and accumulation studies in mouse lung slices using fluorescence microscope
- in the staining of ATP vesicles in mesenchymal stem cells (MSCs)
- in uptake-release assay for characterization of dense granule functionality of platelets
Indications
Quinacrine is no longer used extensively as an antimalarial drug and has been largely replaced by the 4- aminoquinolines.Antimicrobial activity
Mepacrine is active against the asexual erythrocytic stage of all four Plasmodium spp. that infect humans and the gametocytes of P. vivax and P. malariae. The enantiomers have equal antimalarial activity. It exhibits broad activity in experimental models against T. cruzi, Leishmania spp., E. histolytica, Trichomonas vaginalis, G. lamblia and Blastocystis hominis. It is also active against tapeworms.원료
The structural resemblance to chloroquine suggests the likelihood of cross-resistance with that drug, but evidence for this is equivocal.일반 설명
Bright yellowish needles or bright yellow powder. Odorless. pH of a 1% aqueous solution is about 4.5.. Used as an anti-malarial drug. Moderately toxic.공기와 물의 반응
Water soluble.반응 프로필
QUINACRINE DIHYDROCHLORIDE is an acidic salt of an amine. React as a weak acid to neutralize bases.화재위험
Flash point data for QUINACRINE DIHYDROCHLORIDE are not available, but QUINACRINE DIHYDROCHLORIDE is probably combustible.Pharmaceutical Applications
A synthetic acridine derivative, formulated as the hydrochloride for oral use.Pharmacokinetics
Oral absorption: GoodCmax 100 mg oral: 50 μg/L after 1–3 h
Plasma half-life: 5 days
Plasma protein binding: 85%
There is extensive tissue binding and a six-fold concentration into leukocytes from plasma. About 10% of the daily dose is excreted in the urine. It is widely distributed throughout the body.
Clinical Use
GiardiasisProphylaxis of malaria
Tapeworm infections
부작용
Dizziness, headache and gastric problems are common. Toxic psychoses, bone marrow depression, yellow skin and exfoliative dermatitis are described. Poor toleration is noted, especially in children. It should not be used in combination with 8-aminoquinolines.Purification Methods
It crystallises from H2O (solubility is 2.8% at room temperature) as yellow crystals. It is slightly soluble in MeOH and EtOH. The free base crystallises from Me2CO or pet ether with m 86-88o, or aqueous EtOH with 85-87.5o. The bismethiodide has m 224o (from MeOH/EtOAc/Et3N), and the picrate has m 207-208o(dec) when crystallised from Me2CO/EtOH. It is an antimalarial, antiprotozoal and intercalates DNA. [Wolfe Antibiot 3 (Springer-Verlag) 203 1975, Beilstein 22 III/IV 6247, 22/12 V 235.]QUINACRINE DIHYDROCHLORIDE 준비 용품 및 원자재
원자재
준비 용품
QUINACRINE DIHYDROCHLORIDE 공급 업체
글로벌( 146)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 |
sophieliu@speranzachem.com | China | 723 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 |
1015@dideu.com | China | 2263 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34571 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 27644 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9626 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52861 | 58 |
| Alfa Chemistry | +1-5166625404 |
Info@alfa-chemistry.com | United States | 21317 | 58 |