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하이드록시프롤린

하이드록시프롤린 구조식 이미지

카스 번호:: 51-35-4

한글명:: 하이드록시프롤린

동의어(한글):: 하이드록시프롤린;4-하이드록시프롤린

상품명:: L-Hydroxyproline

동의어(영문):: TRANS-4-HYDROXY-L-PROLINE;HYDROXYPROLINE;(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;Hyp;4-Hydroxyproline;4-HYDROXY-L-PROLINE;H-HYP-OH;4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;HYDROXY-L-PROLINE;4R-4-hydroxyproline

CBNumber:: CB8357870

분자식:: C5H9NO3

포뮬러 무게:: 131.13

MOL 파일:: 51-35-4.mol

MSDS 파일:: SDS

속성

안전

MSDS

용도

공급 업체 963

하이드록시프롤린 속성

녹는점: 273 °C (dec.)(lit.)

알파: -75.5 º (c=5, H2O)

끓는 점: 242.42°C (rough estimate)

밀도: 1.3121 (rough estimate)

증기 밀도: 4.5 (vs air)

굴절률: -75.5 ° (C=4, H2O)

저장 조건: Store below +30°C.

용해도: H₂O: 50 mg/mL

물리적 상태: 결정 또는 결정성 분말

산도 계수 (pKa): 1.82, 9.66(at 25℃)

색상: 하얀색

수소이온지수(pH): 5.5-6.5 (50g/l, H2O, 20℃)

냄새: 냄새 없는

optical activity: [α]25/D 75.6°, c = 1 in H2O

수용성: 357.8g/L(20℃)

Merck: 14,4840

BRN: 471933

InChIKey: PMMYEEVYMWASQN-DMTCNVIQSA-N

LogP: -0.350 (est)

CAS 데이터베이스: 51-35-4(CAS DataBase Reference)

NIST: Hydroxyproline(51-35-4)

EPA: trans-4-Hydroxy-L-proline (51-35-4)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi,Xn
위험 카페고리 넘버	36/37/38-22
안전지침서	24/25-36/37/39-27-26
WGK 독일	3
RTECS 번호	TW3586500
TSCA	Yes
위험 등급	IRRITANT
HS 번호	29339990

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P271	옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.

NFPA 704

	1
0		0

하이드록시프롤린 MSDS

(2S,4R)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid

하이드록시프롤린 C화학적 특성, 용도, 생산

개요

A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys.

화학적 성질

White crystalline powder

용도

A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.

정의

ChEBI: An optically active form of 4-hydroxyproline having L-trans-configuration.

생산 방법

In the past L-Hydroxyproline was isolated by hydrolysis of animal collagen, e. g. gelatine or collagen, of which it is a major constituent. L-Hydroxyproline is an unnatural amino acid which is made in the body by hydroxylation of L-Proline. The presence of L-Hydroxyproline and proline are key to maintaining the stability of the tight collagen helix.
Today L-Hydroxyproline is manufactured by bio-catalysed hydroxylation of proline in bacteria. Together with its other isomers, L-Hydroxyproline is also used as an inter mediate for a range of pharmaceutical active ingredients.
Produced by hydroxylation of L-proline after protein synthesis. It is contained rich in collagen and elastin. Known to stabilization of triple-helix structure of collagen. Widely used as an intermediate for medicines.

일반 설명

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Purification Methods

Crystallise it from MeOH/EtOH (1:1). Separation from normal allo-isomer can be achieved by crystallisation of the copper salts [see Levine Biochemical Preparations 8 114 1961]. Separation from proline is achieved via the crystalline picrate, CdCl2, or acid ammonium rhodanate salts [see Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2182 1961, Kapfhammer & Mohn Z Physiol Chem 306 76 1956]. [Beilstein 22/5 V 7.]

하이드록시프롤린 준비 용품 및 원자재

원자재

Soy bean Isoflavone Isoflavone 10-40% Α-PROTEIN Bone glue 카세인 젤라틴

준비 용품

N-Boc-cis-4-Hydroxy-L-proline methyl ester (R)-(-)-3-Pyrrolidinol hydrochloride (2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine tert-부틸2,5-디아자비시클로[2.2.1]헵탄-2-카르복실레이트염산염 N-Boc-4-oxo-L-Proline methyl ester Fmoc-L-하이드록시프롤린 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid 1-Boc-2-하이드록시메틸-4-M… 2-피롤리딘메탄올,4-하이드록시-,염산염(1:1),(2S,4R)- BETONICINE 트랜스-4-하이드록시-1-(4-니트로벤질일록시카르보닐)-L-프롤린 N-CBZ-CIS-4-HYDROXY-D-PROLINE METHYL ESTER 1-벤질피롤 1-페닐피롤

하이드록시프롤린 공급 업체

글로벌( 963)공급 업체

공급자	전화	이메일	국가	제품 수	이점
BTC pharm India	+918790379245	banny.janga@btcpharm.com	India	1269	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@kingfinertech.com	China	3002	58
Hebei Saisier Technology Co., LTD	+86-18400010335 +86-18034520335	admin@hbsaisier.cn	China	940	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	2603	58
Hebei Longbang Technology Co., LTD	+86-18032476855 +86-18032476855	admin@hblongbang.com	China	902	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Taizhou Tianhong Biochemistry Technology Co., Ltd.	0523-86132544	sales@thbiochem.com	CHINA	305	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21688	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55

하이드록시프롤린 관련 검색:

L-(-)-프로린 trans-4-Hydroxy-L-proline methyl ester hydrochloride trans,trans-2,4-Undecadienal trans-4-Hydroxy-D-proline D-Proline CHLOROPHOSPHONAZO III N-Acetyl-L-Hydroxyproline L-PROLINE-(4-3H(N)) L-(+)-Prolinol L-Leucine Methyl L-leucinate hydrochloride cis-4-Hydroxy-L-proline Boc-Hyp-OH cis-4-Hydroxy-D-proline BETONICINE (2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER BOC-HYP(BZL)-OH Fmoc-Hyp(tBu)-OH