3-클로로프로피온산 클로라이드
|
|
3-클로로프로피온산 클로라이드 속성
- 녹는점
- -32 °C
- 끓는 점
- 143-145 °C(lit.)
- 밀도
- 1.33 g/mL at 25 °C(lit.)
- 증기압
- 10.0 hPa
- 굴절률
- n
20/D 1.457(lit.)
- RTECS 번호
- UC3934000
- 인화점
- 146 °F
- 저장 조건
- Flammables area
- 용해도
- 클로로포름, 에틸아세테이트에 용해됨
- 물리적 상태
- 액체
- 색상
- 적갈색
- 수소이온지수(pH)
- <7 (H2O)
- 폭발한계
- 8.8-20.2%(V)
- 수용성
- 물과 반응
- 감도
- Moisture Sensitive
- BRN
- 635814
- 안정성
- 수분에 민감한
- InChIKey
- INUNLMUAPJVRME-UHFFFAOYSA-N
- CAS 데이터베이스
- 625-36-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T+ | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 14-22-26-34-35-10 | ||
| 안전지침서 | 23-26-36/37/39-45-38-16-8 | ||
| 유엔번호(UN No.) | UN 3390 6.1/PG 1 | ||
| WGK 독일 | 1 | ||
| F 고인화성물질 | 21 | ||
| TSCA | Yes | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | I | ||
| HS 번호 | 29159080 | ||
| 기존화학 물질 | KE-05881 |
3-클로로프로피온산 클로라이드 C화학적 특성, 용도, 생산
개요
3-Chloropropionyl chloride is an important bifunctional reagent. It is capable of acylation and possesses a 2-chloro-ethyl fragment (CH2CH2Cl), which can be subjected to nucleophilic substitution and serves as a masked vinyl group. It can be used as a starting material in many reactions to construct a variety of (hetero)cyclic compounds.화학적 성질
Clear colorless to dark brown liquid. Soluble in ethanol, ether and chloroform. Slightly soluble in water.용도
3-Chloropropionyl chloride is a reagent used in the synthesis of Beclamide (B119400), which is a chlorinated benzylpropanamide used as an anticonvulsant drug. It is used in the treatment of tonic-clonic seizyres and has sedative properties.제조 방법
3-Chloropropionyl chloride (1) is commercially available and can be prepared from β-propiolactone (2) and thionyl chloride.1 Other standard methods available for the preparation of acyl chlorides can also be applied: the reaction of acrylic acid (3) or 3-chloropropionic acid (4) with thionyl chloride, phosphoryl chloride, phosgene, or phosphorus trichloride.
화학 반응
(1) The Friedel¨CCrafts acylation of tert-butylbenzene (5) with 3-chloropropionyl chloride (1) followed by cyclization provid- ed indanone 6, which was further transformed into urea derivative 7, a potent TRPV1 antagonist.
(2) A novel high-yielding one-pot microwave-assisted synthesis of condensed 5-substituted pyranoisoquinoline-1,6-diones 9 from 2-substituted isoquinoline-1,3-diones 8 and 3-chloropropionyl chloride (1) was reported.
(3) Acylation of 2-aminophenol (12) with 3-chloropropionyl chloride (1), followed by cyclization in the presence of polyphosphoric acid (PPA), gave benzoxazole 13, which was further reacted with 4-chlorophenyl-1-piperazine to yield the target benzo[d]oxazole analogue 14, a selective dopamine D4 receptor ligand.
3-클로로프로피온산 클로라이드 준비 용품 및 원자재
원자재
준비 용품
Tetrahydro-4-pyranol
5,6-DIHYDRO-4-METHOXY-2H-PYRAN
Tetrahydro-4H-pyran-4-one
카르밤산,[10-[3-(4-MORPHOLINYL)-1-OXOPROPYL]-10H-PHENOTHIAZIN-2-YL]-,에틸에스테르
클로르이소시아네이트(2)
CO-1686
2-피라졸린
3-CHLORO-1-(2-METHYLPHENYL)-1-OXOPROPANE
디아미노에틸아크릴레이트
PYROQUILON
3-클로로-1-(4-메톡시페닐)프로판-1-온
15-디클로로-3-펜타논
3-클로로-N-(2,4-디메틸페닐)프로판아미드
3-클로로-N-사이클로헥실프로파나미드
3-클로로프로피온산 클로라이드 공급 업체
글로벌( 432)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 |
info@edengenechem.com | China | 2169 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 18219 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 2603 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15956 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21688 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 7154 | 58 |
3-클로로프로피온산 클로라이드 관련 검색:
프로피온일 염화물 클로로(3-)피발로일클로라이드 3-클로로프로피온산 클로라이드
2-CHLOROPROPIONYL CHLORIDE,ALPHA-CHLOROPROPIONYL CHLORIDE
2,3-DICHLOROPROPIONYL CHLORIDE
DIMETHYLMALONYL CHLORIDE
Malonyl chloride
DIETHYLMALONIC ACID DICHLORIDE
3-CHLOROTETRAFLUOROPROPIONYL CHLORIDE
Cyclopropanecarbonyl chloride, 2,2-dichloro-1-methyl- (9CI)
3,5,6-TRICHLOROOCTAFLUOROHEXANOYL CHLORIDE
alpha-chloroproionyl chloride
3,4-DICHLOROPENTAFLUOROBUTYRYL CHLORIDE
Fludarabine Phosphate α-Chloropropionyl Chloride
[S,(+)]-2-Chloropropionyl chloride
2-CHLOROPROPIONYL CHLORIDE [1-14C]
[R,(-)]-2-Chloropropionyl chloride
A-CHLOROPROPIONYL CHLORIDE