N,N-디메틸아세트아미드

N,N-디메틸아세트아미드 속성

N,N-디메틸아세트아미드 MSDS

Acetdimethylamide

N,N-디메틸아세트아미드 C화학적 특성, 용도, 생산

용도

디메틸 아세트 아미드 DMAC는 많은 유기 반응 및 산업 분야에 사용되는 양극성 비양 자성 용매입니다. 높은 끓는점과 우수한 열적 화학적 안정성으로 다목적 용제입니다.

용도

일반적으로 유기 합성에서 극성 용매로 사용됩니다.

개요

Dimethylacetamide (DMAC) is a synthetic organic compound that is produced from a reaction of dimethylamine and acetic acid or acetic anhydride. It is a colorless to yellow liquid with a faint odor resembling ammonia. DMAC has similar density to water and is miscible with water and organic substances. This organic compound is commonly associated with many industrial uses, either as a starting material or an intermediate. DMAC is a good solvent that is used in polymer dissolution, especially in the fiber industry. Historically, DMAC was also tested as a possible antineoplastic agent in a phase 1 study involving 17 patients. However, liver and central nervous system (CNS) toxicity associated with DMAC was observed and these patients had altered mental states, resulting in no further drug development.

화학적 성질

Dimethylacetamide occurs as a clear, colorless, slightly hygroscopic liquid with a weak ammonia-like or fish-like odor. odor threshold concentration is 46.8 ppmv (Leonardos et al., 1969). It is soluble in a wide variety of solvents.

용도

N,N-dimethylacetamide is an excellent solvent and often acts as a catalyst in halogenation, cyclization, and alkylation reactions. It is an important industrial solvent for polyacrylonitrile, vinyl resins, cellulose derivatives, styrene polymers and linear polyesters. It is also used in all analytical laboratories as a major component of mobile phase in High Performance Liquid Chromatography (HPLC) and in Liquid Chromatography - Mass Spectrometry (LC-MS). N,N-dimethylacetamide lithium chelate complexes intercalate cationic sites in layered silicates.

주요 응용

N,N-Dimethylacetamide is primarily used as an industrial solvent and intermediate in the manufacture of pharmaceuticals, fine chemicals, agrochemicals, polymers, and resins. It is also used as a spinning solvent in the production of fibers of various polymers, including acrylic, polyurethane, polyurea copolymer, and meta-aramid. Moreover, this aprotic dipolar solvent is also used in X-ray and photographic products and in the production of polyimide films. The polyimide films are produced for a variety of industries, including consumer electronics, solar photovoltaic and wind energy, aerospace, automotive, and industrial applications. N,N-Dimethylacetamide has other minor uses, including removal of ink, stripping of paint, and also for laboratory use.

정의

ChEBI: N,N-dimethylacetamide is a member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It is a member of acetamides and a monocarboxylic acid amide. It is functionally related to an acetamide.

제조 방법

N,N-Dimethylacetamide is prepared by reaction of dimethylamine with acetic acid, acetic anhydride, or acetate esters. Heating dimethylamine acetate with, or without a catalyst affords N,N-Dimethylacetamide. Reaction of dimethylamine with acetate esters requires a catalyst; sodium methoxide is typically used.

일반 설명

Dimethylacetamide appears as a clear colorless liquid with a faint odor similar to ammonia. About the same density as water. Flash point 145°F. Vapors heavier than air. May by toxic by skin absorption. May irritate eyes and skin.

공기와 물의 반응

Water soluble.

반응 프로필

N,N-Dimethylacetamide is an amide. Incompatible with oxidizing agents and halogenated compounds. Exothermic reactions occur with carbon tetrachloride and hexachlorocyclohexane. N,N-Dimethylacetamide can react violently in the presence of iron. Special Hazards of Combustion Products: Emits carbon oxides, nitrogen oxides, and dimethylamine when heated to decomposition.

건강위험

A study of 41 workers who had been exposed to dimethylacetamide from 2 to 10 years revealed the occurrence of disorders reflecting liver damage (Corsi, 1971). Retention of bromosulfophthalein was increased in 9 of 10 workers who had been exposed to dimethylacetamide for 7 to 10 years, and in 10 of 20 workers who had been exposed to dimethylacetamide for 2 to 7 years. Other parameters of hepatic function which were altered in the exposed individuals include proteinemia, cholesterolemia, activities of hepatic transaminases and alkaline phosphatase in serum, and bilirubinemia. Hepatomegaly was diagnosed in 14 workers.
In a clinical trial, dimethylacetamide was administered to patients with advanced malignancies and caused abnormal mental states (Weiss et al 1962a, b). This effect was observed at a dose of 400 mg/kg given daily for 3 or more days.
The symptoms were not seen at 300 mg/kg or lower. The second or third dose caused depression, lethargy, occasional confusion or disorientation. The fourth or fifth dose produced striking hallucinations, perceptual distortions and delusions in all nine patients. All patients reverted to normal several days after discontinuation of treatment with dimethylacetamide.

화재위험

N,N-Dimethylacetamide is combustible.

공업 용도

Dimethylacetamide is a powerful industrial solvent, the uses of which are very similar to those of dimethylformamide (Siegle, 1980). Its strong solvent action renders it particularly useful in the manufacture of films and fibers and as a solvent for polyacrylonitrile, polyvinyl chloride, polyamides, cellulose derivatives and polystyrenes and in coatings and adhesive formulations. Dimethylacetamide dissolves many inorganic salts.

Safety Profile

Moderately toxic by skin contact, inhalation, intravenous, and intraperitoneal routes. Mildly toxic by ingestion. Experimental teratogenic and reproductive effects. A skin and eye irritant. Less toxic than dimethylformamide. Mutation data reported. Combustible when exposed to heat and flame. A moderate explosion hazard. Violent reaction with halogenated compounds (e.g., carbon tetrachloride, hexachlorocyclohexane) when heated above 9OOC. Iron powder catalyzes the reaction so that it initiates at 71OC. When heated to decomposition it emits toxic fumes of NOx

Safety

Dimethylacetamide is used in pharmaceutical preparations as a solvent in parenteral formulations and is generally regarded as a nontoxic material when used as an excipient. Animal toxicity studies indicate that dimethylacetamide is readily absorbed into the bloodstream following inhalation or topical application. Repeated exposure to dimethylacetamide may be harmful and can result in liver damage. High intravenous doses (>400mg/kg/day for 3 days) may be hallucinogenic.
LD50 (rabbit, SC): 9.6g/kg(11) LD50 (rat, IP): 2.75g/kg LD50 (rat, IV): 2.64g/kg LD50 (rat, oral): 4.93g/kg LD50 (mouse, inhalation): 7.2g/kg LD50 (mouse, IP): 2.8g/kg

Carcinogenicity

DMAC was not carcinogenic in rats administered 100, 300, or 1000 mg/kg/day in drinking water for 2 years. Rats and mice were exposed by inhalation to 0, 25, 100, or 350 ppm DMAC for 6 h/day, 5 days/week for 18 months (mice) or 2 years (rats). DMAC was not oncogenic under these conditions in either the rat or the mouse.

환경귀착

Chemical/Physical. Releases toxic fumes of nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).

신진 대사

33 mg or 92 mg of 14C-labelled DMAC were given by gavage to two rats. The major urinary components were:60-70% MMAC, 7-10% N -hydroxymethylacetamide, 7- 10%, Acetamide and some residual DMAC. A small proportion of DMAC and its intermediates was hydrolysed and eliminated as Carbon Dioxide.
Twenty male rats were given two subcutaneous injections of 300 mg DMAC, MMAC and Acetamide were found in the urine.
20 rats had 20-80% DMAC solutions (0.12 ml) applied to their backs. The amount of MMAC increased as the solution concentration increased. Recovery ranged from 13% for the 20% solution to 42% for undiluted DMAC (Du Pont, 1988).
These studies show that the major metabolic pathway of DMAC "in vivo" in rats is sequential N-demethylation and elimination from the body.
https://hpvchemicals.oecd.org/ui/handler.axd?id=16564422-daff-4489-8c27-735d3ab0b260

저장

Dimethylacetamide should be stored in an airtight container, protected from light, in a cool, dry place. Dimethylacetamide has an almost unlimited shelf-life when kept in closed containers and under nitrogen. It is combustible.

Purification Methods

Shake the amide with BaO for several days, reflux it with BaO for 1hour, then fractionally distil it under reduced pressure. Store it over molecular sieves. [Beilstein 4 IV 180.]

비 호환성

Dimethylacetamide is incompatible with carbon tetrachloride, oxidizing agents, halogenated compounds, and iron. It attacks plastic and rubber. Contact with strong oxidizers may cause fire.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM injections, IV injections and infusions). Included in parenteral medicines licensed in the UK.

N,N-디메틸아세트아미드 준비 용품 및 원자재

원자재

준비 용품

N,N-디메틸아세트아미드 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shandong Yanshuo Chemical Co., Ltd.	+86-18678179670 +86-18615116763	sales@yanshuochem.com	China	101	58
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
Qingdao Trust Agri Chemical Co.,Ltd	+8613573296305	aroma@qdtrustagri.com	China	165	58
Shandong Zhishang New Material Co., Ltd.	+8617653113209	sales002@sdzschem.com	China	3050	58
Shandong Quark Chemical Co., Ltd.	+8613325218432	sales@quarkchem.com	China	57	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
shandong exelon biochem co.ld	+86-533-2119995 +8615053330977	451614802@QQ.com	China	28	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18224	58
Hunan aslsen technology co.,ltd	+8615308460054	aslsc@aslsen.com	China	128	58

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