Rubitecan
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Rubitecan 속성
- 녹는점
- 182-186°C
- 알파
- D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4)
- 끓는 점
- 816.3±65.0 °C(Predicted)
- 밀도
- 1.63
- 인화점
- 106℃
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- DMSO, 클로로포름, 메탄올에 용해됨
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 11.16±0.20(Predicted)
- 색상
- 노란색
- Merck
- 14,8288
- CAS 데이터베이스
- 91421-42-0(CAS DataBase Reference)
안전
| 안전지침서 | 24/25 | ||
|---|---|---|---|
| WGK 독일 | 3 | ||
| RTECS 번호 | UQ0493300 | ||
| HS 번호 | 29399990 |
Rubitecan C화학적 특성, 용도, 생산
개요
Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.화학적 성질
Yellow Amorphous Powder정의
ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.Rubitecan 준비 용품 및 원자재
원자재
준비 용품
Rubitecan 공급 업체
글로벌( 189)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10247 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 |
info@shochem.com | CHINA | 288 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Rubitecan 관련 검색:
이산화질소
(+)-Camptothecin
9-Aminocamptothecin
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-9-methoxy-, (4S)-
SN-38-D3
7-Ethyl-20(R)-camptothecin
daurisoline
2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one
L-Hyoscyamine
Xanthiazone
VERATRINE
veratramine
VERATRIDINE
menisdaurin
Daurinoline
Xanthiside
20R-Camptothecin
Camptothecin