Bortezomib manufacturers and suppliers

Bortezomib suppliers

Properties

Melting point:: 122-124°C

Density: 1.214

RTECS: ED7771666

storage temp.: Inert atmosphere,Store in freezer, under -20°C

solubility: Soluble in chloroform, dimethyl sulfoxide, ethanol and methanol.

form: solid

pka: 9.66±0.43(Predicted)

color: White

Stability:: Hygroscopic and Moisture Sensitive

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H300-H310-H330-H372

Precautionary statements: P301+P310a-P304+P340-P320-P330-P405-P501a

Risk Statements: 23/24/25-48/23/24/25

Safety Statements: 9-27-36/37-45-60

HazardClass: 6.1

HS Code: 29339900

Use

Bortezomib belong to the class of drugs called proteasome inhibitors and is licensed in the United States and the United Kingdom for the treatment of multiple myeloma. The drug has been licensed for patients in whom the myeloma has progressed despite prior treatment or where a bone marrow transplant is not possible or was not successful. It is marketed under the name Velcade? or Cytomib?. Velcade is administered via injection and is sold as powder for reconstitution. Bortezomib was the first drug approved in the new drug class of proteasome inhibitors and boron seems to be its active element. For the mode of action, it is believed that the boron atom binds with high affinity and specificity to the catalytic site of 26S proteasome and inhibits its action. Therapy with Bortezomib can lead to a variety of adverse reactions, including peripheral neuropathy, myelosuppression, renal impairment and gastrointestinal (GI) disturbances together with changes in taste. Nevertheless, the side effects are in most cases less severe than with alternative treatment options such as bone marrow transplantation.

You can find Bortezomib suppliers, manufacturers, and distributors from countries such as CHINA, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.