Galantamine Hydrobromide suppliers
Galantamine Hydrobromide
- CAS:
- 1953-04-4
- MF:
- C17H22BrNO3
- MW:
- 368.27
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Properties
- Melting point:
- 256 °C
- alpha
- D20 -93.1° (c = 0.1015 in 15 ml H2O)
- refractive index
- -95 ° (C=1.4, H2O)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Sparingly soluble in water, very slightly soluble in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
- form
- White to off-white crystalline solid.
- color
- White to Orange to Green
- Water Solubility
- Soluble in water or DMSO
- Merck
- 14,4340
- InChI
- InChI=1/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/s3
- InChIKey
- QORVDGQLPPAFRS-ORFATOSYNA-N
- SMILES
- [C@@]123CCN(C)CC4=CC=C(OC)C(O[C@H]1C[C@@H](O)C=C2)=C34.Br |&1:0,14,16,r|
- LogP
- 1.750 (est)
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301
- Precautionary statements
- P264-P270-P301+P310-P405-P501
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 45-36/37/39-22
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- DF8075000
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29399990
- Toxicity
- LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess)
Use
Galantamine hydrobromide is a kind of tertiary amino alkaloid and is a reversible competitive inhibitor of cholinesterase. With the deepened understanding of the Alzheimer’s disease (AD) pathogenesis, people have started the study of using this product for treating AD in the early 1980s. In 1987, the United States scholars Bonnie had first successfully receive a patent of applying galantamine hydrobromide for treatment of AD. After this, many countries, one after another, have carried out related pharmacological, pharmacodynamic and pharmacokinetic studies related to it. This result had showed that galantamine hydrobromide, as the second-generation cholinesterase inhibitors, targeted on nerve synapses by competing with acetylcholine for binding to the cholinesterase and further blocking this enzymatic degradation of acetylcholine and therefore increasing the acetyl choline concentration inside the brain.
295 supplier list of "Galantamine Hydrobromide"
- Product Name:Galantamine hydrobromide
- Products Intro:Purity: 99% | Package: 5kg;1KG;0.5KG; 0.1KG;,0.01KG/BAG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: VK2 MK7 0.2%~2%,S-Adenosyl-L-methionine Disulfate Tosylate (SAME),Citicoline CAS 987-78-0,PQQ(Pyrroloquinoline Quinone Disodium Salt),D-chiro-inositol
$0.00/ 25KG
- Product Name:Galantamine Hydrobromide
- Products Intro:Purity: 99% | Package: 25KG
- Company Type: Service provider
- Country/Region: CHINA
- Main Products: carbomer,lead acetate,phenylacetamide,Xylazine,Xylazine hcl
- Product Name:Galantamine Hydrobromide
- Products Intro:Purity: 99.8% | Package: 1kg;45USD|25kg;40USD|100kg;35USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 5449-12-7,28578-16-7,Semaglutide,Tirzepatide,BDO
$0.00/ 1kg
- Product Name:Ferumoxytol
- Products Intro:Purity: 99% | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
$0.00/ 1kg
- Product Name:Galantamine Hydrobromide
- Products Intro:Purity: 99% | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: plant-based ingredients,natural vegan ingredients,clean-label raw materials
$8.00/ 1kg
- Product Name:Galantamine Hydrobromide
- Products Intro:Purity: 99% | Package: 1kg; 8USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
$10.00/ 1KG
- Product Name:Galantamine Hydrobromide
- Products Intro:Purity: 99% | Package: 1KG;10USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: DHA,4'-Methylpropiophenone,Procaine hcl,tetramisole hcl,lidocaine