Mefenamic acid manufacturers and suppliers

Mefenamic acid suppliers

Properties

Melting point:: 230 °C

Boiling point:: 384.06°C (rough estimate)

Density: 1.0944 (rough estimate)

refractive index: 1.5200 (estimate)

storage temp.: 2-8°C

solubility: Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides

pka: 4.2(at 25℃)

color: White to Pale Yellow

Water Solubility: It is soluble in acetone, chloroform, dichloromethane, methanol. Insoluble in water.

Merck: 14,5798

InChIKey: HYYBABOKPJLUIN-UHFFFAOYSA-N

LogP: 5.120

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P301+P312+P330

Hazard Codes: Xn

Risk Statements: 22-40-20/21/22

Safety Statements: 22-36

WGK Germany: 3

RTECS: CB4550000

HS Code: 28142000

Toxicity: LD50 orally in mice, rats: 630, 790 mg/kg (Jahn, Adrian)

Use

Mefenamic acid (Ponstel, Ponstan) is one of the oldestNSAIDs, introduced into the market in 1967 for mild tomoderate pain and for primary dysmenorrhea. It is rapidly absorbed with peak plasma levels occurring 2 to 4 hoursafter oral administration. It undergoes hepatic benzylic hydroxylationof its 3'methyl group regioselectively into twoinactive metabolites, 3'-hydroxymethylmefenamic acid andthe 3'carboxylate metabolite (via further oxidation of thebenzylic alcohol group). The parent drugs and these metabolitesare conjugated with glucuronic acid and excreted primarilyin the urine. Thus, although patients with knownliver deficiency may be given lower doses, it is contraindicatedin patients with preexisting renal dysfunction.Common side effects associated with its use include diarrhea,drowsiness, and headache. The possibility of blood disordershas also prompted limitation of its administration to 7days. It is not recommended for children or during pregnancy.

You can find Mefenamic acid suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.