Valrubicin manufacturers and suppliers

Valrubicin suppliers

Properties

Melting point:: 116-117 °C

Boiling point:: 135-136 C

Density: 1.3473 (estimate)

storage temp.: 2-8°C

solubility: DMSO (Slightly), Methanol (Slightly)

form: Solid

pka: 7.34±0.60(Predicted)

color: Red

Water Solubility: insoluble

InChIKey: ZOCKGBMQLCSHFP-XGMQQLFPNA-N

SMILES: C12=C(O)C3=C(C(=O)C4C=CC=C(OC)C=4C3=O)C(O)=C1C[C@@](O)(C(=O)COC(=O)CCCC)C[C@@H]2O[C@@H]1O[C@H]([C@@H](O)[C@@H](NC(=O)C(F)(F)F)C1)C |&1:21,34,36,38,39,41,r|

Safety Information

Symbol(GHS): GHS08,GHS06

Signal word: Danger

Hazard statements: H351-H340-H312-H332-H360-H301

Precautionary statements: P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-37/39

HS Code: 2941906000

Toxicity: dnd-hmn:lym 3 mg/L CJBIAE 58,720,80

Use

Valrubicin was launched as a new 'chemotherapeutic agent for the treatment of bladder cancer, particularly in patients with BCG-refractory carcinoma in situ (CIS) of the bladder for whom immediate cystectomy is unacceptable. It belongs to the class of anthracyclines, the widest used in human cancers, and is a N-trifluoroacetyl 14-valerate derivative of doxorubicin.Valrubicin can be obtained in 3 steps from daunomycin by N-trifluoroacetylation of the sugar moiety then iodination of the 2-acetyl group and introduction of a valerate residue. A proposed mechanism involved in the cytotoxicity of Valrubicin coud be the blockade of SV40 large T antigen helicase; this cellular enzyme is involved in the formation of a ternary complex with DNA to maintain the topographic structure of DNA during transcription. In patients with CIS of bladder refractory to front line and second line therapies, intravesical instillation of Valrubicin resulted in a complete response with a significant rate and allowed a delay in cystectomy. Systemic absorption was minimal and accordingly produced a lower incidence of cardiotoxicity compared with doxorubicin.

You can find Valrubicin suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.