Vildagliptin suppliers
Vildagliptin
- CAS:
- 274901-16-5
- MF:
- C17H25N3O2
- MW:
- 303.4
Suppliers by country/region
Company Type
Properties
- Melting point:
- 153-155?C
- alpha
- -78.3° (c = 9.73 in methanol)
- Boiling point:
- 531.3±50.0 °C(Predicted)
- Density
- 1.27
- Flash point:
- 275.1℃
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in DMSO (up to 45 mg/ml), in DMF (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml).
- form
- solid
- pka
- 15.05±0.40(Predicted)
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months
- InChI
- InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1
- InChIKey
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N
- SMILES
- N1(C(CNC23CC4CC(CC(O)(C4)C2)C3)=O)CCC[C@H]1C#N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H332-H335
- Precautionary statements
- P261-P280-P305+P351+P338
- Risk Statements
- 28-38-41-48
- Safety Statements
- 24/25-26-28-36/37/39
- RIDADR
- 3077
- HS Code
- 29339900
Use
Vildagliptin, a DPP-4 inhibitor, was launched for the oral treatment of type 2 diabetes. Vildagliptin is the second DPP-4 inhibitor to reach the market behind sitagliptin, which was introduced in 2006. DPP-4 inhibitors act by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase the synthesis and release of insulin from pancreatic βcells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic α cells, which leads to reduced hepatic glucose production. However, although GLP-1 and GIP effectively lower blood glucose, they are short-lived as a result of rapid inactivation by the ubiquitous serine protease DPP-4. By inhibiting DPP-4, vildagliptin increases the concentration and duration of active incretin levels, which in turn results in increased insulin release and decreased glucagon levels in a glucose-dependent manner. Both vildagliptin and sitagliptin are potent, competitive, reversible inhibitors of DPP- 4 (IC50=3.5 and 18 nM, respectively), and they both show slow, tight-binding inhibition kinetics.
444 supplier list of "Vildagliptin"
$0.00-0.00 / 10g
- Product Name:Vildagliptin
- Products Intro:Purity: 99% HPLC|Package: 10g;0.00;USD|100g;0.00;USD|1000g;0.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Semaglutide,Tirzepatide,Retatrutide,Cholecystokinin,Cagrilintide
$0.10-0.10 / 1KG
- Product Name:Vildagliptin
- Products Intro:Purity: 98.0%|Package: 1KG;0.10;USD|1KG;0.10;USD
- Company Type: Trader
- Country/Region: CHINA
$0.00/ 1kg
- Product Name:Vildagliptin
- Products Intro:Purity: 0.99|Package: 1kg;0.00;USD
- Company Type: Manufacturer
- Country/Region: CHINA
- Main Products: lead acetate,Lead oxide,PMK ethyl glycidate,BMK Glycidic Acid,Diethyl(phenylacetyl)malonate
$19.10/ 1KG
- Product Name:Vildagliptin
- Products Intro:Purity: 99%|Package: 1KG;19.10;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: acetic acid,Ethyl oleate,Hypophosphorous acid,tetramisole,OPP
$34.00-1.10 / 1kg
- Product Name:Vildagliptin
- Products Intro:Purity: 99% | Package: 1kg;34USD|1000kg;1.1USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Chemical raw materials,Organic raw materials,Petrochemicals,Chemical reagents,Intermediates
- Product Name:Vildagliptin
- Products Intro:Purity: 99.8% | Package: 1kg;35USD|25kg;30USD|100kg;25USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: retatrutide,bpc157,Semaglutide,Tirzepatide,tb500
$0.00/ 1kg
- Product Name:Vildagliptin
- Products Intro:Purity: 99% | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
$0.00/ 1g
- Product Name:Vildagliptin
- Products Intro:Purity: More Than 99% | Package: 1g
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical Chemicals,Apis,Pharmaceutical Intermediates,Electronic Chemicals,OLED Intermediates