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ChemicalBook >> CAS DataBase List >>Vildagliptin

Vildagliptin suppliers

Vildagliptin

CAS:
274901-16-5
MF:
C17H25N3O2
MW:
303.4

Properties

Melting point:
153-155?C
alpha 
-78.3° (c = 9.73 in methanol)
Boiling point:
531.3±50.0 °C(Predicted)
Density 
1.27
Flash point:
275.1℃
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 45 mg/ml), in DMF (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml).
form 
solid
pka
15.05±0.40(Predicted)
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months
InChI
InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1
InChIKey
SYOKIDBDQMKNDQ-XWTIBIIYSA-N
SMILES
N1(C(CNC23CC4CC(CC(O)(C4)C2)C3)=O)CCC[C@H]1C#N

Safety Information

Symbol(GHS) 
GHS hazard pictograms
GHS07
Signal word 
Warning
Hazard statements 
H302-H315-H319-H332-H335
Precautionary statements 
P261-P280-P305+P351+P338
Risk Statements 
28-38-41-48
Safety Statements 
24/25-26-28-36/37/39
RIDADR 
3077
HS Code 
29339900

Use

Vildagliptin, a DPP-4 inhibitor, was launched for the oral treatment of type 2 diabetes. Vildagliptin is the second DPP-4 inhibitor to reach the market behind sitagliptin, which was introduced in 2006. DPP-4 inhibitors act by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase the synthesis and release of insulin from pancreatic βcells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic α cells, which leads to reduced hepatic glucose production. However, although GLP-1 and GIP effectively lower blood glucose, they are short-lived as a result of rapid inactivation by the ubiquitous serine protease DPP-4. By inhibiting DPP-4, vildagliptin increases the concentration and duration of active incretin levels, which in turn results in increased insulin release and decreased glucagon levels in a glucose-dependent manner. Both vildagliptin and sitagliptin are potent, competitive, reversible inhibitors of DPP- 4 (IC50=3.5 and 18 nM, respectively), and they both show slow, tight-binding inhibition kinetics.

444 supplier list of "Vildagliptin"

Vildagliptin Vildagliptin 2Photos

$0.00-0.00 / 10g

  • Product Name:Vildagliptin
  • Products Intro:Purity: 99% HPLC|Package: 10g;0.00;USD|100g;0.00;USD|1000g;0.00;USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Semaglutide,Tirzepatide,Retatrutide,Cholecystokinin,Cagrilintide
  • Product Name:Vildagliptin
  • Products Intro:Purity: 99% | Package: 100G; 1KG; 5KG; 25KG | CustNote: Pharmaceutical grade
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Shilajit,herb extract,Creatine Monohydrate,Curcumin,Nicotinamide
Vildagliptin Vildagliptin 2Photos

$0.10-0.10 / 1KG

  • Product Name:Vildagliptin
  • Products Intro:Purity: 98.0%|Package: 1KG;0.10;USD|1KG;0.10;USD
  • Company Type: Trader
  • Country/Region: CHINA

$0.00/ 1kg

  • Product Name:Vildagliptin
  • Products Intro:Purity: 0.99|Package: 1kg;0.00;USD
  • Company Type: Manufacturer
  • Country/Region: CHINA
  • Main Products: lead acetate,Lead oxide,PMK ethyl glycidate,BMK Glycidic Acid,Diethyl(phenylacetyl)malonate
Vildagliptin Vildagliptin 2Photos

$19.10/ 1KG

  • Product Name:Vildagliptin
  • Products Intro:Purity: 99%|Package: 1KG;19.10;USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: acetic acid,Ethyl oleate,Hypophosphorous acid,tetramisole,OPP
Vildagliptin Vildagliptin 2Photos

$34.00-1.10 / 1kg

  • Product Name:Vildagliptin
  • Products Intro:Purity: 99% | Package: 1kg;34USD|1000kg;1.1USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Chemical raw materials,Organic raw materials,Petrochemicals,Chemical reagents,Intermediates
  • Product Name:Vildagliptin
  • Products Intro:Purity: 99.8% | Package: 1kg;35USD|25kg;30USD|100kg;25USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: retatrutide,bpc157,Semaglutide,Tirzepatide,tb500
Vildagliptin Vildagliptin 2Photos

$0.00/ 1kg

  • Product Name:Vildagliptin
  • Products Intro:Purity: 99% | Package: 1kg
  • Company Type: Trader
  • Country/Region: CHINA
Vildagliptin Vildagliptin 2Photos

$0.00/ 1g

  • Product Name:Vildagliptin
  • Products Intro:Purity: More Than 99% | Package: 1g
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Pharmaceutical Chemicals,Apis,Pharmaceutical Intermediates,Electronic Chemicals,OLED Intermediates
  • Product Name:Vildagliptin
  • Products Intro:Purity: 98% Min. | Package: 1G;1KG;100KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
You can find Vildagliptin suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

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