400827-46-5 Basic information More..
Product Name:TAK 599
Synonyms:TAK 599;Ceftaroline fosaMil;PPI 0903;TAK-599 (ceftaroline fosamil);Ceftaroline Fosamil Acetate;C22H22N8O8PS4. C2H3O2;TAK-599; CEFTAROLINE FOSAMIL;TAK599; TAK 599;PPI-0903;PPI0903;PPI 0903;Ceftaroline fosamil acetate salt
CAS:400827-46-5
MF:C24H25N8O10PS4
MW:744.72
EINECS:
Mol File:400827-46-5.mol
400827-46-5

Use

Ceftaroline fosamil, also referred to as TAK-599, is a cephalosporin antibacterial agent that was approved in the United States in October 2010 for the IV treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). Ceftaroline fosamil is the water-soluble, N-phosphono prodrug of ceftaroline (T-91825), a broad-spectrum, bactericidal agent with potent activity against methicillin-resistant Staphylococcus aureus (MRSA) strains, multidrug resistant S. pneumonia, and common gram-negative organisms. Ceftaroline binds to PBP2a as well as other PBPs with high affinity and, as a result, retains potent activity. Ceftaroline exhibits activity against most gram-positive pathogens, including β-lactam-susceptible and -resistant S. aureus, vancomycin-resistant S. aureus, and resistant and susceptible forms of S. pneumoniae but has weak activity against Enterococcus sp. The gram-negative antibacterial activity of ceftaroline is limited mainly to respiratory pathogens such as Moraxella catarrhalis and Haemophilus influenzae.

TAK 599 manufacturers

  • TAK 599
  • US $7.00 / kg
  • 2019-07-06
  • CAS: 400827-46-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
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