| | 251456-60-7 Basic information More.. |
| Product Name: | M344 | | Synonyms: | M344;HISTONE DEACETYLASE INHIBITOR III;4-DIMETHYLAMINO-N-(6-HYDROXYCARBAMOYLHEXYL)-BENZAMIDE;N-HYDROXY-7-(4-DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE;4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, MS 344, D237, N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide;4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide;MS 344;M 344 (enzyme inhibitor) | | CAS: | 251456-60-7 | | MF: | C16H25N3O3 | | MW: | 307.39 | | EINECS: | | | Mol File: | 251456-60-7.mol |  |
Use
M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).
- M344
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- US $1.00 / g
- 2019-12-26
- CAS:51456-60-7
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 200kg
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251456-60-7
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