Use
Interferon alfa-n3, Alferon N, is an α-interferon expressedfrom human leukocytes that are antigen-stimulated withavian Sendai virus.Interferon alfa-n3 is indicated for intralesional treatment ofrefractory or recurrent condyloma acuminata (genital warts)in patients 18 years of age or older. These warts are associatedwith human papillomavirus (HPV). Interferon alfa-n3 is especiallyuseful in patients who have not responded well to othermodalities (podophyllin resin, surgery, laser, or cryotherapy).Interferon alfa-n3 is also being investigated for the treatmentof non-Hodgkin lymphoma, herpes simplex virus, rhinovirus,vaccinia, and varicella zoster. A usual dose in condylomaacuminata is 250,000 IU/wart, injected with a 30-gauge needlearound the base of the lesion.Interferon alfa-n3 is contraindicated in persons sensitive tomouse immunoglobulin G (IgG), egg protein, and neomycin.Interferon alfa-n3 is supplied as a solution with the proteinin phosphate-buffered saline with phenol as a preservative.The solution should be stored at 2°C to 8°C withoutfreezing. Properly stored solution expires at 18 months.