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| | Botiacrine Basic information |
| Product Name: | Botiacrine | | Synonyms: | 9,9-dimethylacridine-10-carbothioic acid S-(2-dimethylaminoethyl) ester;S-(2-dimethylaminoethyl) 9,9-dimethylacridine-10-carbothioate;Botiacrine;10-[2-(Dimethylamino)ethylthiocarbonyl]-9,9-dimethylacridan;10(9H)-Acridinecarbothioic acid, 9,9-dimethyl-, S-[2-(dimethylamino)ethyl] ester | | CAS: | 4774-53-2 | | MF: | C20H24N2OS | | MW: | 340.48 | | EINECS: | | | Product Categories: | | | Mol File: | 4774-53-2.mol |  |
| | Botiacrine Chemical Properties |
| Boiling point | 450.2±55.0 °C(Predicted) | | density | 1.144±0.06 g/cm3(Predicted) | | pka | 8.46±0.28(Predicted) |
| | Botiacrine Usage And Synthesis |
| Originator | Botiacrine,ZYF Pharm Chemical | | Manufacturing Process | To 1 gramm-equivalent (g-eq) of dimethylaminoethanethiol in 150 ml of ether,
a suspension of g-eq of 50% sodium hydride in 50-ml of anhydrous ether was
added. After boiling for 1 hour, the reaction mixture was cooled to 0°C,
whereupon g-eq of 9,9-dimethylacridan-10-carboxylic acid chloride (prepared
from 9,9-dimethylacridan and phosghene - cf. Swiss Specification No.
426,821) were added and the mixture was heated for a further 6 hours to
boiling temperature. After cooling to ambient temperature, the precipitated
sodium chloride was filtered in a Buchner funnel fitted with a filter cell. The
corresponding 9,9-dimethylacridan-10-carboxylic aciddimethylaminoethanethiol
ester was immediately precipitated out of filtrate as
base, which melted at 110.5°-111°C. Ethanesulphonic acid salt melted at
147°-150°C. | | Therapeutic Function | Antiparkinsonian |
| | Botiacrine Preparation Products And Raw materials |
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