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2A PharmaChem USA
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| Pengitoxin Basic information |
Product Name: | Pengitoxin | Synonyms: | pentaacetylgitoxin;Pentaacetate;Card-20(22)-enolide, 16-(acetyloxy)-3-[(O-3,4-di-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)- | CAS: | 7242-04-8 | MF: | C51H74O19 | MW: | 991.12 | EINECS: | 230-645-5 | Product Categories: | | Mol File: | 7242-04-8.mol | |
| Pengitoxin Chemical Properties |
Melting point | 151-155° | alpha | D20 +14.0 ±1.5° (c = 1.6 in pyridine) | Boiling point | 742.94°C (rough estimate) | density | 1.1187 (rough estimate) | refractive index | 1.6500 (estimate) | Water Solubility | 11.89mg/L(temperature not stated) |
Toxicity | LD50 in mice (mg/kg): 6.4 i.p.; in rats (mg/kg): 21.0 i.v. (Foerster) |
| Pengitoxin Usage And Synthesis |
Originator | Pengitoxin,Shanghai Lansheng | Manufacturing Process | Gitoxin is isolated from leaves of Digitalis purpurea L. genus Scrofphulariaceae. 10.0 g pure gitoxin are boiled under reflux with 1 L pure acetic anhydride. Gitoxin thereby goes into solution in the course of 1 h. The boiling is discontinued after 1 h and the acetic anhydride distilled off in a vacuum as completely as possible. After taking up the oily residue with 500 ml chloroform, the solution is successively washed with 200 ml of 2 N potassium bicarbonate solution, 0.1 N hydrochloric acid and water. After drying the chloroform solution with anhydrous sodium sulfate, the chloroform is first distilled off over an open flame and then on a water bath at 40°C in a vacuum, a substantially crystalline residue thereby being obtained. The 12.8 g of crude product obtained are recrystallized from 12 times the amount of a mixture of pyridine, methanol and water (25:10:65) to give rhombic crystals, melting point 151°-155°C. | Therapeutic Function | Cardiotonic |
| Pengitoxin Preparation Products And Raw materials |
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