Pengitoxin

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Company Name: 2A PharmaChem USA  
Tel: (630) 737-0988
Email: sales@2apharmachem.com
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Company Name: 3B Scientific Corporation  
Tel: 847.281.9822
Email: sales@3bsc.com
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Pengitoxin Basic information
Product Name:Pengitoxin
Synonyms:pentaacetylgitoxin;Pentaacetate;Card-20(22)-enolide, 16-(acetyloxy)-3-[(O-3,4-di-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)-
CAS:7242-04-8
MF:C51H74O19
MW:991.12
EINECS:230-645-5
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Mol File:7242-04-8.mol
Pengitoxin Structure
Pengitoxin Chemical Properties
Melting point 151-155°
alpha D20 +14.0 ±1.5° (c = 1.6 in pyridine)
Boiling point 742.94°C (rough estimate)
density 1.1187 (rough estimate)
refractive index 1.6500 (estimate)
Water Solubility 11.89mg/L(temperature not stated)
Safety Information
ToxicityLD50 in mice (mg/kg): 6.4 i.p.; in rats (mg/kg): 21.0 i.v. (Foerster)
MSDS Information
Pengitoxin Usage And Synthesis
OriginatorPengitoxin,Shanghai Lansheng
Manufacturing ProcessGitoxin is isolated from leaves of Digitalis purpurea L. genus Scrofphulariaceae.
10.0 g pure gitoxin are boiled under reflux with 1 L pure acetic anhydride. Gitoxin thereby goes into solution in the course of 1 h. The boiling is discontinued after 1 h and the acetic anhydride distilled off in a vacuum as completely as possible. After taking up the oily residue with 500 ml chloroform, the solution is successively washed with 200 ml of 2 N potassium bicarbonate solution, 0.1 N hydrochloric acid and water. After drying the chloroform solution with anhydrous sodium sulfate, the chloroform is first distilled off over an open flame and then on a water bath at 40°C in a vacuum, a substantially crystalline residue thereby being obtained. The 12.8 g of crude product obtained are recrystallized from 12 times the amount of a mixture of pyridine, methanol and water (25:10:65) to give rhombic crystals, melting point 151°-155°C.
Therapeutic FunctionCardiotonic
Pengitoxin Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Potassium bicarbonate-->Acetic anhydride
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