| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Perlapine
CAS:1977-11-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:Perlapine
CAS:1977-11-3
Purity:NULL Package:100mg;10mg;1mg;25mg;50mg;5mg;25mg;5mg Remarks:NULL
|
|
| | perlapine Basic information |
| Product Name: | perlapine | | Synonyms: | 6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepin;AW 14-2333;HF 2333;Hypnodin;6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine;6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine;11H-Dibenz[b,e]azepine, 6-(4-methyl-1-piperazinyl)- | | CAS: | 1977-11-3 | | MF: | C19H21N3 | | MW: | 291.39 | | EINECS: | | | Product Categories: | | | Mol File: | 1977-11-3.mol |  |
| | perlapine Chemical Properties |
| Melting point | 136-138° | | Boiling point | 423.4°C (rough estimate) | | density | 1.0521 (rough estimate) | | refractive index | 1.6080 (estimate) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 5 mg/ml | | form | A crystalline solid | | pka | 8.00±0.20(Predicted) | | color | White |
| Toxicity | LD50 in male, female mice, rats (mg/kg): 61, 61, 60, 66 i.v.; 250, 300, 480, 420 s.c., 270, 280, 660, 720 orally (Yokotani) |
| | perlapine Usage And Synthesis |
| Uses | Perlapine exhibits antipsychotic activity and blocks dopamine and serotonin receptors. Perlapine is also a novel agonist of hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD). | | Uses | Perlapine is an atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively). Perlapine is also an agonist for hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M3 receptor that activates neuronal firing. Perlapine displays >10,000-fold selectivity for hM3Dq over hM3. | | Definition | ChEBI: Perlapine is an organic molecular entity. | | storage | Room temperature |
| | perlapine Preparation Products And Raw materials |
|