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| | 1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE Basic information |
| Product Name: | 1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE | | Synonyms: | (3E)-4-(4-Methoxyphenyl)-3-buten-2-one;4-Methoxystyrylmethyl ketone;Methoxybenzalacetone;p-Anisylideneacetone;4-(4-methoxyphenyl)-3-buten-2-one (en);4-Methoxybenzalacetone;4'-Methoxybenzylideneacetone;4-Methoxybenzylideneacetone | | CAS: | 943-88-4 | | MF: | C11H12O2 | | MW: | 176.21 | | EINECS: | 213-404-9 | | Product Categories: | | | Mol File: | 943-88-4.mol |  |
| | 1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE Chemical Properties |
| Melting point | 75-77° | | Boiling point | 267.83°C (rough estimate) | | density | 1.0558 (rough estimate) | | refractive index | 1.5100 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Very Slightly) | | form | Solid | | color | White or yellowish leafy crystals. | | LogP | 2.25 | | EPA Substance Registry System | 3-Buten-2-one, 4-(4-methoxyphenyl)- (943-88-4) |
| HazardClass | IRRITANT | | HS Code | 2914500090 | | toxicity | Both the acute oral LD50 value in rats and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Wohl, 1974). |
| | 1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE Usage And Synthesis |
| Occurrence | Has apparently not been reported to occur in nature. | | Uses | 4-(4-methoxyphenyl)-3-buten-2-one is used in preparation of Thiazole derivatives as protein secretion inhibitors. | | Preparation | From anisaldehyde and acetone by condensation using a suitable catalyst. | | Metabolism | When the side chain of a mixed ketone contains a double bond, both the keto group and the double bond are potentially reducible in vivo. In a related material, methyl styryl ketone ( C6 H5 CH:CHCOCH3 ) , the keto group appears to be more readily reduced than the double bond,with reduction via C6 H5 CH:CH.CH(OH)CH3to the completely reduced carbinol compoundC6 H5[CH2]2CH(OH) CH3, which is found as the main product (Fischer & Bielig, 1940). The ether link is relatively stable in substituted anisoles, such as anethole (p-CH3OC 6H4CH:CH CH4), containinga potential carboxyl group attached to the aromatic ring (Williams, 1959). |
| | 1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE Preparation Products And Raw materials |
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