| Company Name: |
Shanghai Hekang Biotechnology Co., Ltd.
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| Tel: |
18939837085 |
| Email: |
youchemicals@gmail.com |
| Products Intro: |
Product Name:11-(4-METHYL-1-PIPERAZINYL)-5H-DIBENZO(B,E)(1,4)DIAZEPINE
CAS:1977-07-7
Purity:98%+ Package:1g, 5g, 10g, 25g, 100g, 1kg, 1000kg Remarks:A0340
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 15221909166 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
CAS:1977-07-7
Purity:98% Package:1;
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| | 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Basic information |
| Product Name: | 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine | | Synonyms: | 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;Dechloroclozapine;5H-Dibenzo[b,e][1,4]diazepine, 11-(4-methyl-1-piperazinyl)-;11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepineQ: What is
11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine Q: What is the CAS Number of
11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;Dopamine serotonin antagonist-1;inhibit,Inhibitor,Muscarinic acetylcholine receptor,hM4Di,Deschloroclozapine,hM3Dq,muscarinic-based,mAChR,DREADDs | | CAS: | 1977-07-7 | | MF: | C18H20N4 | | MW: | 292.38 | | EINECS: | | | Product Categories: | | | Mol File: | 1977-07-7.mol |  |
| | 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Chemical Properties |
| Boiling point | 457.5±55.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO : ≥ 83.3 mg/mL (284.90 mM) | | pka | 7.82±0.20(Predicted) | | form | solid | | color | Yellow |
| | 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Usage And Synthesis |
| Biological Activity | Deschloroclozapine is a potent, high-affinity, selective, metabolically stable agonist of muscarinic-based DREADDs. | | in vitro | Deschloroclozapine has greater potencies for DREADDs than previous agonists in vitro. Deschloroclozapine is a potent agonist for hM 3 Dq with an EC 50 =0.13 nM. Deschloroclozapine is also a potent agonist for hM 4 Di with an EC 50 =0.081 nM.
Deschloroclozapine is a potent and selective agonist for hM 3 Dq and hM 4 Di, it does not display significant agonistic activity for any of the 318 tests wild-type GPCRs at <10 nM. b> | | target | Ki: 6.3 nM (hM 3 Dq), 4.2 nM (hM 4 Di) | | storage | Room temperature |
| | 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Preparation Products And Raw materials |
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