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| | 2'-deoxy-2'-fluoro-2'-C-methylcytidine Basic information |
| Product Name: | 2'-deoxy-2'-fluoro-2'-C-methylcytidine | | Synonyms: | (2'R)-2'-deoxy-2'-fluoro-2'-methyl-Cytidine;PSI-6130;R 1656;PSI 6130;4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyr;2'-deoxy-2'-fluoro-2'-C-methylcytidine;R 1656;ethyl 4-broMo-1-Methyl-pyrrole-2-carboxylate;4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimi;4-AMino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidin-2(1H)-one | | CAS: | 817204-33-4 | | MF: | C10H14FN3O4 | | MW: | 259.23 | | EINECS: | 200-001-2 | | Product Categories: | apis | | Mol File: | 817204-33-4.mol |  |
| | 2'-deoxy-2'-fluoro-2'-C-methylcytidine Chemical Properties |
| Melting point | 216-218℃ | | Boiling point | 482.4±55.0 °C(Predicted) | | density | 1.67 | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Methanol (Slightly), Water (Slightly) | | pka | 12.86±0.70(Predicted) | | form | Solid | | color | White to Light Brown | | Stability: | Hygroscopic |
| | 2'-deoxy-2'-fluoro-2'-C-methylcytidine Usage And Synthesis |
| Description | PSI-6130 is a nucleoside inhibitor of the NS5B RNA polymerase of hepatitis C virus (HCV; Ki = 4.3 μM). It inhibits HCV genotype 1b (GT-1b) Con1 and GT-1a H77 viral replication in Huh7 replicon cells using a luciferase-based assay (EC50s = 0.51 and 0.30 μM, respectively). PSI-6130 also inhibits replication of HCV GT-1b and GT-1a replicons from clinical isolates, with EC50 values ranging from 0.60 to 1.41 μM, and 0.20 to 0.43 μM, respectively, in the same assay. It has little or no activity against West Nile Virus (WNV), Dengue type 2 virus (DV), human immunodeficiency virus (HIV), or hepatitis B virus (HBV; EC90s = 46.3, >100, >100, and >10 μM, respectively). | | Uses | PSI-6130 is an experimental treatment for hepatitis C. PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI-6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B. | | target | Hepatitis C Virus Nucleoside |
| | 2'-deoxy-2'-fluoro-2'-C-methylcytidine Preparation Products And Raw materials |
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