- Sesamol
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- $120.00 / 1kg
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2024-05-21
- CAS:533-31-3
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10ton
- Sesamol
-
- $0.00 / 1kg
-
2024-05-15
- CAS:533-31-3
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1 ton
- Sesamol
-
- $0.00 / 1kg
-
2024-05-15
- CAS:533-31-3
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1 ton
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| | Sesamol Chemical Properties |
| Melting point | 62-65 °C (lit.) | | Boiling point | 113-116°C 2mm | | density | 1.2112 (rough estimate) | | refractive index | 1.4850 (estimate) | | Fp | 113-116°C/2mm | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform, Methanol | | form | crystalline | | pka | 10.08±0.20(Predicted) | | color | off-white to tan | | Water Solubility | slightly soluble | | Sensitive | Light Sensitive | | BRN | 127405 | | InChIKey | LUSZGTFNYDARNI-UHFFFAOYSA-N | | LogP | 1.253 (est) | | CAS DataBase Reference | 533-31-3(CAS DataBase Reference) | | NIST Chemistry Reference | 1,3-Benzodioxol-5-ol(533-31-3) | | EPA Substance Registry System | Sesamol (533-31-3) |
| | Sesamol Usage And Synthesis |
| Description | Sesamol is found in sesame seeds and sesame oil. It is a well-known antioxidant. It has antioxidant, chemoprevention, antimutagenic, and antihepatotoxic activities and can induce the apoptosis of cancer and cardiovascular cells. It can be used in the synthesis of paroxetine.
| | Reference | [1] M. A. Ansari, Z. Fatima, S. Hameed, Sesamol: A Natural Phenolic Compound with Promising Anticandidal Potential, Journal of Pathogens, vol. 2014, Article ID 895193.
[2] T. Geetha, B. Rohit, K. Pal, Sesamol: an efficient antioxidant with potential therapeutic benefits, Medicinal Chemistry, 2009, vol. 5, pp. 367-371.
[3] Amin F. Majdalawieh, Zeenah R. Mansour. “Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action.” European journal of pharmacology 855 (2019): Pages 75-89. | | Chemical Properties | off-white to beige crystalline powder | | Uses | Sesamol (Paroxetine Anhydrous EP Impurity B) is a natural component of sesame oil with antioxidant activity. Sesamol has potential protective effects against free radicals as well as some antifungal activity. Sesamol can also be used as an intermediate in the preparation of antidepressants such as Paroxetine (P205750). | | Definition | ChEBI: Sesamol is a member of benzodioxoles. | | benefits |
Sesamol, 5-hydroxy-1,3-benzodioxole or 3,4-methylene-dioxyphenol, is a water-soluble phenolic lignan isolated from roasted sesame seeds and processed sesame oil. Various studies investigated the anti-cancer therapeutic potential of sesamol, and the literature provided reveals compelling evidence that sesamol acts as a metabolic regulator and possesses antioxidant, anti-mutagenic, anti-hepatotoxic, anti-inflammatory, anti-aging, and chemopreventive properties.
| | Synthesis Reference(s) | Tetrahedron Letters, 19, p. 3085, 1978 DOI: 10.1016/S0040-4039(01)94947-0 | | General Description | Sesamol, a principal phytophenol of sesame oil lignans, is typically used as a dietary compound.(10) | | Biological Activity | Sesamol has a wide range of biological actions including inhibition of lipid peroxidation and enhancement of radical scavenging, upregulation of antioxidant enzymes, suppression of TNFα 80 and IL-1β expression, inhibition of NF-κB 81 signaling, suppression of LOX-1 82 and 5-LOX activity, induction of 83 apoptosis, arresting cell growth at different phases of the cell cycle; and modulation of caspase-3, p53, Bax, and Bcl2 expression[3].
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| | Sesamol Preparation Products And Raw materials |
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