| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Phosphodiesterase, 3',5'-cyclic-nucleotide-specific from bovine brain
CAS:9040-59-9
Purity:15-30 units/mg protein (in the presence of 0.03 mM Ca2+ and Package:2UN Remarks:P9529-2UN
|
|
| | 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Basic information |
| Product Name: | 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE | | Synonyms: | 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE;3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE;phosphodiesterase 3':5'-cyclic*nucleotide crude C;Phosphodiesterase, cyclic 3',5'-nucleotide;PHOSPHODIESTERASE 3':5'-CYCLIC*NUCLEOTID E FROM BOVI;PHOSPHODIESTERASE 3':5'-CYCLIC*NUCLEOTID E CRUDE COM;Phosphodiesterasefrombovinebrain;3',5'-cyclic-nucleotide 5'-nucleotidohydrolase from bovine brain | | CAS: | 9040-59-9 | | MF: | | | MW: | 0 | | EINECS: | 232-920-5 | | Product Categories: | | | Mol File: | Mol File | ![3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Structure]() |
| | 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Chemical Properties |
| storage temp. | -20°C | | form | lyophilized powder |
| | 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Usage And Synthesis |
| Uses | Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain has been used to assay the protein activator, calmodulin and in in vitro adenylate cyclase assay. | | Uses | For use in calmodulin (P 0270) assay. Activity is reduced to <50% without calmodulin present. | | General Description | Phosphodiesterase (PDE1) exists in two isoforms -PDE1A2 and PDE1B1. The enzyme has a role in the complex interaction between cyclic nucleotides and Ca2+ second-messenger systems. | | Biochem/physiol Actions | Hydrolyzes the 3′,5′-phosphodiester bond in cyclic nucleotide monophosphates, such as cAMP and cGMP, to the corresponding nucleotide 5′-monophosphate. | | Clinical Use | Phosphodiesterase-3 (PDE3) is an enzyme responsible for degradation of cAMP to AMP in platelets
and blood vessels. Selective cAMP PDE3 inhibitors, such as dipyridamole and cilostazol , inhibit the degradation of cAMP, thereby increasing cellular concentration of cAMP and
leading to inhibition of platelet aggregation and vasodilation. |
| | 3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE Preparation Products And Raw materials |
|