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APROBARBITAL METHANOL SOLUTION

APROBARBITAL METHANOL SOLUTION Basic information
Product Name:APROBARBITAL METHANOL SOLUTION
Synonyms:Allopropylbarbital;alurateelixirverdum;Aprobarbita;Aprobarbitone;Aprozal;Isonal;isonal(swedish);Isopropylallylbarbituric acid
CAS:77-02-1
MF:C10H14N2O3
MW:210.23
EINECS:200-997-4
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:77-02-1.mol
APROBARBITAL METHANOL SOLUTION Structure
APROBARBITAL METHANOL SOLUTION Chemical Properties
Melting point 140-141.5°
Boiling point 349.75°C (rough estimate)
density 1.2056 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka7.81±0.10(Predicted)
color White to Off-White
Water Solubility 4.121g/L(25 ºC)
Safety Information
Hazard Codes F,T
Risk Statements 11-23/25-36/38
Safety Statements 16-24-45
Hazardous Substances Data77-02-1(Hazardous Substances Data)
ToxicityLD50 i.p. in mice: 200 mg/kg (Frey)
DEA Controlled SubstancesCSCN: 2100
CSA SCH: Schedule III
NARC: No
MSDS Information
APROBARBITAL METHANOL SOLUTION Usage And Synthesis
OriginatorAlurate,Roche
UsesControlled substance (depressant). Sedative, hypnotic.
DefinitionChEBI: A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by an isopropyl and a prop-1-en-3-yl group at position 5.
Manufacturing Process170 parts of isopropylbarbituric acid are mixed with 500 parts of water and dissolved by adding 135 parts of a 30 percent of the solution of sodium hydroxide. To this solution are added 130 parts of 130 parts of allylbromide. An emulsion obtained is stirred at an inner temperature of about 25°C. The reaction is at first accompanied by a slight development of heat. After 12 hours the reaction is brought to a close. When cooled down the isopropylallylbarbituric acid is drawn off. The yield is more than 80 percent of the theoretically calculated quantity. By crystallization from diluted alcohol the pure isopropylallylbarbituric acid is obtained in colorless crystals of the melting point 137-138°C.
Therapeutic FunctionSedative, Hypnotic
World Health Organization (WHO)Aprobarbital is an intermediate-acting barbiturate. See WHO comment for barbiturates.
APROBARBITAL METHANOL SOLUTION Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Allyl bromide-->5-ISOPROPYLBARBITURIC ACID
Tag:APROBARBITAL METHANOL SOLUTION(77-02-1) Related Product Information
5-(2-bromoallyl)-5-(1-methylpropyl)-1H,3H,5H-pyrimidine-2,4,6-trione methohexital sodium SECOBARBITAL 5-ISOPROPYLBARBITURIC ACID Narcobarbital Methohexital APROBARBITAL METHANOL SOLUTION BARBITAL Barbituric acid Probarbital SECOBARBITAL-D5 (1-METHYL-D3, BUTYL-2,2-D2) (R)-(+)-Seconal S(-)-Secobarbital sodium 5-allyl-5-isopropylbarbiturate R(+)-Secobarbital sodium S(-)-Secobarbital sodium TALBUTAL CIII (250 MG) CYCLOPENTOBARBITAL