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| | Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- Basic information |
| Product Name: | Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- | | Synonyms: | Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-;avermectin H2B1b;Component B1b;22,23-Dihydro-34-nor-5-O-demethylavermectin A1a;22,23-Dihydro-5-O-demethyl-25-de(1-methylpropyl)-25-isopropylavermectin A1a;22,23-Dihydroavermectin B1b;Dihydroavermectin B1b;5-O-Demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A1a | | CAS: | 70209-81-3 | | MF: | C47H72O14 | | MW: | 861.07 | | EINECS: | 274-384-5 | | Product Categories: | | | Mol File: | 70209-81-3.mol |  |
| | Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- Chemical Properties |
| Boiling point | 934.1±65.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | | form | A solid | | pka | 12.42±0.70(Predicted) | | Stability: | Temperature sensitive |
| RIDADR | 2588 | | HazardClass | 6.1(a) | | PackingGroup | II |
| | Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- Usage And Synthesis |
| Uses | Ivermectin B1b is a minor component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19. | | Uses | Ivermectin B1b (dihydroavermectin B1b) is the minor component (<20%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectin/milbemycins are also potent insecticides. In vitro, the B1b (25-iso-propyl) analogue is slightly more potent than the 25-sec-butyl (B1a) analogue as an inhibitor of nematode larval development and paralysis, and also a more sensitive probe for ivermectin resistance. | | Definition | ChEBI: A macrocyclic lactone that is avermectin B1b in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the minor component of ivermectin. | | Brand name | Stromectol (Merck). |
| | Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- Preparation Products And Raw materials |
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