| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
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Product Name:Trimidox
CAS:95933-74-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:TRIMIDOX
CAS:95933-74-7
Purity:98% Package:5mg; 50mg; 10mg; 100mg Remarks:Medbio
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
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marketing@energy-chemical.com |
| Products Intro: |
Product Name:Trimidox
CAS:95933-74-7
Purity:NULL Package:10mg;5mg Remarks:NULL
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Trimidox
CAS:95933-74-7
Purity:98% Package:5mg;10mg;50mg
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| Company Name: |
ApexBio Technology
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| Tel: |
+ 1-832-696-8203 |
| Email: |
sales@apexbt.com |
| Products Intro: |
Product Name:Trimidox
CAS:95933-74-7
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|
| | TRIMIDOX Basic information |
| Product Name: | TRIMIDOX | | Synonyms: | TRIMIDOX;VF 233;Trimidox Exclusive;MSLJYSGFUMYUDX-UHFFFAOYSA-N;4-[amino-(hydroxyamino)methylidene]-2,6-dihydroxycyclohexa-2,5-dien-1-one;Benzenecarboximidamide, N,3,4,5-tetrahydroxy-;N,3,4,5-TETRAHYDROXY-BENZENECARBOXIMIDAMIDE | | CAS: | 95933-74-7 | | MF: | C7H8N2O4 | | MW: | 184.15 | | EINECS: | | | Product Categories: | | | Mol File: | 95933-74-7.mol |  |
| | TRIMIDOX Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide | | form | crystalline solid |
| | TRIMIDOX Usage And Synthesis |
| Description | Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 μM. | | Uses | Trimidox is a specific ribonucleotide reductase inhibitor. | | Definition | ChEBI: Trimidox is a benzenetriol. | | references | [1] szekeres t, fritzer m, strobl h, et al. synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia hl-60 cells[j]. blood, 1994, 84(12): 4316-4321.
[2] elledge s j, zhou z, allen j b. ribonucleotide reductase: regulation, regulation, regulation[j]. trends in biochemical sciences, 1992, 17(3): 119-123. |
| | TRIMIDOX Preparation Products And Raw materials |
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