3,4-DICHLOROISOCOUMARIN

3,4-DICHLOROISOCOUMARIN Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:3,4-dci
CAS:51050-59-0
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:3,4-dichloroisocoumarin
CAS:51050-59-0
Purity:0.99 Package:1kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:3,4 Dichloroisocoumarin
CAS:51050-59-0
Purity:97.94% Package:1mg;38USD|5mg;89USD|10mg;155USD
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: CAS:51050-59-0
Purity:Min98% HPLC/GC Package:1KG;1USD
Company Name: Hefei Hirisun Pharmatech Co., Ltd
Tel: +8615056975894
Email: shawn@hirisunpharm.com
Products Intro: Product Name:3,4-dichloroisoCoumarin
CAS:51050-59-0
Purity:0.95 Package:1G;5G;25G;Bulk for inquiry Remarks:HR012642

3,4-DICHLOROISOCOUMARIN manufacturers

3,4-DICHLOROISOCOUMARIN Basic information
Product Name:3,4-DICHLOROISOCOUMARIN
Synonyms:3,4-dci;3,4-DICHLORO-2-BENZOPYRAN-1-ONE;3,4-DICHLOROISOCOUMARIN;3,4-dichloroisochromen-1-one;3,4-dichloro-1H-isochroMen-1-one;3,4-DCI, 3,4-Dichloro-2-benzopyran-1-one;3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem;1H-2-Benzopyran-1-one, 3,4-dichloro-
CAS:51050-59-0
MF:C9H4Cl2O2
MW:215.03
EINECS:
Product Categories:
Mol File:51050-59-0.mol
3,4-DICHLOROISOCOUMARIN Structure
3,4-DICHLOROISOCOUMARIN Chemical Properties
Boiling point 304.7±42.0 °C(Predicted)
density 1.53±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMF or DMSO at a concentration of 10mM
form White lyophilized solid
color White to off-white
BRN 6802625
Safety Information
Hazard Codes T
Risk Statements 25-36/37/38
Safety Statements 26-36
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
HazardClass 6.1
MSDS Information
ProviderLanguage
SigmaAldrich English
3,4-DICHLOROISOCOUMARIN Usage And Synthesis
Description3,4-Dichloroisocoumarin (3,4-DCI) is a serine protease inhibitor. It completely inhibits enzyme activity of 24 serine proteases including human leukocyte elastase, thrombin, plasmin, Factor Xa, and Factor XIIa in vitro. 3,4-DCI stimulates caseinolytic activity of bovine pituitary multicatalytic proteinase complex (MPC) by inducing a conformational change in the MPC that exposes the caseinolytic active site. It has been used to functionally characterize the catalytic activities of multiple proteases including rat liver MPC and extracellular lipase.
UsesUseful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors. It is an inhibitor of Chymotrypsin and Trypsin. ,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases.
DefinitionChEBI: 3,4-dichloroisocoumarin is a member of the class of isocoumarins that is isocoumarin substituted by chloro groups at positions 3 and 4. It is a serine protease inhibitor. It has a role as a geroprotector and a serine protease inhibitor. It is a member of isocoumarins and an organochlorine compound.
General DescriptionA potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 μM.
Biochem/physiol ActionsProduct does not compete with ATP.
3,4-DICHLOROISOCOUMARIN Preparation Products And Raw materials
Tag:3,4-DICHLOROISOCOUMARIN(51050-59-0) Related Product Information
(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE N-ACETYL-EGLIN C ACTINONIN glutamyl-glycyl-arginine chloromethyl ketone Coumarin VINYL BENZOATE Chloromethyl ethyl ether 1H-2-Benzopyran-1-one Benzyl chloromethyl ether CIS-1,2-DICHLOROETHYLENE 2-Chloro-6-fluorobenzyl chloride Chloromethyl acetate 2-(Chloromethyl)benzoic acid 3,4-DICHLOROISOCOUMARIN Methyl 2-chloromethylbenzoate BETA-CHLOROSTYRENE CHLOROMETHYL BENZOATE 1-((E)-2-CHLORO-VINYL)-2-METHYL-BENZENE