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3-Chloropropiononitrile

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Products Intro: Product Name:3-Chloropropiononitrile
CAS:542-76-7
Purity:98% Package:1KG;100USD
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Products Intro: Product Name:3-chloropropanenitrile
CAS:542-76-7
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Products Intro: Product Name:3-Chloropropiononitrile
CAS:542-76-7
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Products Intro: Product Name:3-Chloropropiononitrile
CAS:542-76-7
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
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Products Intro: Product Name:3-Chloropropiononitrile
CAS:542-76-7
Purity:0.98 Package:1kg 5kg 10kg 206kg kilograms per barrel

3-Chloropropiononitrile manufacturers

  • 3-Chloropropiononitrile
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  • $15.00 / 1KG
  • 2021-07-02
  • CAS:542-76-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
3-Chloropropiononitrile Basic information
Product Name:3-Chloropropiononitrile
Synonyms:3-chloro-propanenitril;3-chloro-Propanenitrile;3-Chloropropanenitrile-Chloroethylcyanide;3-Chloropropanonitrile;3-chloro-propionitril;3-Chloropropuinitrile;3-Chlorpropannitril;CH2ClCH2CN
CAS:542-76-7
MF:C3H4ClN
MW:89.52
EINECS:208-827-0
Product Categories:API Intermediate;C1 to C5;Cyanides/Nitriles;Nitrogen Compounds;Organics
Mol File:542-76-7.mol
3-Chloropropiononitrile Structure
3-Chloropropiononitrile Chemical Properties
Melting point ?52-?50 °C (lit.)
Boiling point 174-176 °C (lit.)
density 1.144 g/mL at 25 °C (lit.)
refractive index n20/D 1.438(lit.)
Fp 168 °F
storage temp. Store below +30°C.
solubility 45g/l
form clear liquid
color Colorless to Almost colorless
Water Solubility 4.50 g/100 mL
Merck 14,2160
BRN 1098454
CAS DataBase Reference542-76-7(CAS DataBase Reference)
NIST Chemistry ReferenceCl(CH2)2CN(542-76-7)
EPA Substance Registry System3-Chloropropionitrile (542-76-7)
Safety Information
Hazard Codes T+
Risk Statements 23-28
Safety Statements 36/37/39-45
RIDADR UN 3276 6.1/PG 2
WGK Germany 3
RTECS UG1400000
TSCA Yes
HazardClass 6.1
PackingGroup II
HS Code 29269095
Hazardous Substances Data542-76-7(Hazardous Substances Data)
ToxicityLD50 orally in mice, rats: 9, 100 mg/kg, Fassett in Industrial Hygiene and Toxicology vol. 2, F. A. Patty, Ed. (Interscience, New York, 2nd ed., 1962) pp 2025-2026
MSDS Information
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3-Chloropropiononitrile English
SigmaAldrich English
ALFA English
3-Chloropropiononitrile Usage And Synthesis
Description3-Chloropropionitrile is a combustible, colorless liquid with an acrid odor. Molecular weight =89.53;Boiling point=175-176℃ (decomposes); Flashpoint =76℃. Hazard Identification (based on NFPA-704 MRating System): Flammability 2, Reactivity 1
Chemical Properties3-Chloropropionitrile is a combustible, colorless liquid with an acrid odor
Uses3-Chloropropionitrile is used in pharmaceutical and polymer synthesis.
UsesIn pharmaceutical and polymer synthesis. Combines the reactivity of a nitrile and an alkyl halide. Because of the cyano group the chlorine atom is more reactive than in ordinary alkyl halides.
Production Methods3-Chloropropionitrile [542-76-7], 3-chloropropanenitrile, b-chloropropionitrile, ClCH2 CH2CN, Mr 89.53, mp-51℃, bp 175 –176℃ (101.3 kPa), n20D 1.4360, d204 1.1573, is a colorless liquid miscible with acetone, benzene, ethanol and diethyl ether. It can be obtained by hydrochlorination of acrylonitrile with hydrochloric acid [49] and is used as an organic intermediate in the synthesis of the H2-receptor famotidine.
General DescriptionColorless liquid with a characteristic acrid odor. Used in pharmaceutical and polymer synthesis.
Reactivity ProfileToxic gas (hydrogen chloride) is released when the compound is heated above 266 F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat. [EPA, 1998].
HazardToxic by ingestion, inhalation, and skin contact. Combustible.
Health HazardToxic effects are a result of systemic cyanide poisoning. (Non-Specific -- Cyanide) Few poisons are more rapidly lethal. Average oral lethal dose for hydrogen cyanide is approximately 60-90 mg (corresponds to 200 mg of potassium cyanide). Cause of death is lack of oxygen to the body's cells (especially the brain and heart) as a result of the chemical inhibiting cell enzymes.
Fire HazardToxic gas (hydrogen chloride) is released when the compound is heated above 266F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat.
Potential ExposureThis material is used in pharmaceutical manufacture and in polymer synthesis.
First aidIf this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
Use amyl nitrate capsules if symptoms develop. All areaemployees should be trained regularly in emergency measures for cyanide poisoning and in CPR. A cyanide antidotekit should be kept in the immediate work area and must berapidly available. Kit ingredients should be replaced every12 years to ensure freshness. Persons trained in the use ofthis kit, oxygen use, and CPR must be quickly available.
storageColor Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Before entering confined space where 3-chloropropionitrile may be present, check to make sure that an explosive concentration does not exist. Store in tightly closedcontainers in a cool, well-ventilated area. Metal containersinvolving the transfer of this chemical should be groundedand bonded. Where possible, automatically pump liquidfrom drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use onlynonsparking tools and equipment, especially when openingand closing containers of this chemical. Sources of ignition,such as smoking and open flames, are prohibited where thischemical is used, handled, or stored in a manner that couldcreate a potential fire or explosion hazard.
ShippingUN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).
IncompatibilitiesContact with strong oxidizers may cause a fire and explosion hazard
Tag:3-Chloropropiononitrile(542-76-7) Related Product Information
3-Aminopropionitrile [3-[[[2-(DiaMinoMethyleneaMino)-4-thiazolyl]Methyl]thio]propionyl]sulfaMide Hydrochloride (FaMotidine IMpurity) Sulfamide FAMOTIDINE RELATED COMPOUND B 2-(4-(CHLOROMETHYL)THIAZOL-2-YL)GUANIDINE 3-[2-(Diaminomethyleneamino)-1,3-thiazol-4-ylmethylsulphinyl]-N-sulphamoyl propanamide Bis[(2-guanidino-4-thiazolyl)methyl]disulfide (S)-((2-Guanidino-4-thiazolyl)methylisothiourea dihydrochloride 3-(2-Guanidino-thiazol-4-yl-methylthio)-propionitrile 3-(((2-GUANIDINO-4-THIAZOLYL)METHYL)THIO)PROPANIMIDC ACID METHYL ESTER Famotidine 3-[2-(Diaminomethyleneamino)-1,3-thiazol-4-ylmethylsulphinyl]-N-sulphamoylpropanamidine FaMotidine Acid IMpurity 3-Hydroxypropionic acid N-DesaMinosulfonyl-N-cyano FaMotidine FaMotidine Acid IMpurity Methyl Ester 3-HYDROXYPROPIONAMIDE FaMotidine AMide IMpurity