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| | oxophenarsine Basic information |
| Product Name: | oxophenarsine | | Synonyms: | 2-Amino-4-arsenosophenol;Oxarsan;Phenarsen;(3-Amino-4-hydroxyphenyl)arsenous acid;3-Amino-4-hydroxyphenylarsinoxide;538-03-4 (Mono-hydrochloride);63951-03-1 (Mono-hydrochloride salt);Brn 3235865 | | CAS: | 306-12-7 | | MF: | C6H6AsNO2 | | MW: | 199.04 | | EINECS: | 206-178-8 | | Product Categories: | | | Mol File: | 306-12-7.mol |  |
| | oxophenarsine Chemical Properties |
| Melting point | 133°C (rough estimate) | | Boiling point | 117.4°C | | form | solid | | color | Bright-yellow deliquescent powder or white crystals |
| Toxicity | LDLo orl-mus: 150 mg/kg JPETAB 76,358,42 |
| | oxophenarsine Usage And Synthesis |
| Definition | ChEBI: Oxophenarsine is a substituted aniline. | | Brand name | Mapharsen (Parke-Davis). | | Industrial uses | Palladium dissolves in hot oxidising acids. Palladium is used as a hydrogenation catalyst, for H2/D2/T2separation and purification as well as a catalyst
in the Wacker process. The Wacker process, which facilitates the oxidation of ethylene to acetaldehyde, was
the first organopalladium reaction that was applied on an industrial scale. | | Safety Profile | Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx and As | | Enzyme inhibitor | This sulfhydryl-reactive arsenical (FW = 199.04 g/mol; CAS 306-12-7), variously named Mapharsen, Ehrlich-5, oxyphenarsine, oxarsan, arsinoxide, 3-amino-4-hydroxybenzenearsenoxide, and 2-amino-4-arsenosophenol, was originally developed by Nobelist Paul Ehrlich as an anti-syphilis drug. (Note: do not confuse this compound with oxophenylarsine, also known phenylarsine oxide). It is now used as an antiprotozomal agent, particularly against Trypanosoma. Oxophenarsine is typically supplied as the hydrochloride (FW = 235.50 g/mol) and is readily soluble in water. (See also Dichlorophenarsine) Target(s): acetyl-CoA acyltransferase; actomyosin ATPase; aldehyde dehydrogenase; alkaline phosphatase; asparagine synthetase; ATPase, rat brain; ATPase, trypanosomal; cathepsin; cholinesterase; deoxyribonuclease; diisopropylfluorophosphatase; γ-glutamyl hydrolase, or pteroylglutamate conjugase; glyceraldehyde-3-phosphate dehydrogenase; a-glycerophosphate oxidase; hexokinase; myosin ATPase; pyrophosphatase; pyruvate decarboxylase; pyruvate oxidase; ribose-5-phosphate isomerase; succinate dehydrogenase; succinate oxidase; urease. |
| | oxophenarsine Preparation Products And Raw materials |
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