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| | CHAETOMIN Basic information |
| Product Name: | CHAETOMIN | | Synonyms: | Monoclonal Anti-HSF4 antibody produced in mouse;DKFZp313O1039;SSFA2;ANTI-HSF4 antibody produced in mouse;HSF4;CTM;CS-1;CHETOMIN | | CAS: | 1403-36-7 | | MF: | C31H30N6O6S4 | | MW: | 710.87 | | EINECS: | | | Product Categories: | | | Mol File: | 1403-36-7.mol |  |
| | CHAETOMIN Chemical Properties |
| Melting point | 218-220℃ (chloroform ) | | density | 1.78±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble | | form | Off-white to fawn solid. | | pka | 12.69±0.10(Predicted) | | color | Off-white to fawn |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | Toxicity | rat,LD50,oral,75mg/kg (75mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 174, 1980. |
| | CHAETOMIN Usage And Synthesis |
| Uses | Chetomin is an antibacterial agent and inhibitor of HIF. | | Definition | ChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity. | | Biochem/physiol Actions | Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes. | | storage | +4°C |
| | CHAETOMIN Preparation Products And Raw materials |
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