| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Poly-L-histidine
CAS:26062-48-6
Purity:mol wt 5,000-25,000 Package:100MG Remarks:P9386-100MG
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| Company Name: |
Beijing OKA biological technology co., LTD
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| Tel: |
010-010-62971590 18548936886 |
| Email: |
3462612863@qq.com |
| Products Intro: |
Product Name:Poly-L-histidine
CAS:26062-48-6
Purity:分子量5,000-25,000 Package:10mg;50mg
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| | POLY-L-HISTIDINE HYDROCHLORIDE MW Basic information |
| | POLY-L-HISTIDINE HYDROCHLORIDE MW Chemical Properties |
| | POLY-L-HISTIDINE HYDROCHLORIDE MW Usage And Synthesis |
| Uses | Poly-L-histidine has been used:
- as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)
- as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane
- in screening its anti-prion activity in cell based and in vivo anti-prion assay
| | Definition | ChEBI: Histidine is an alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3. It has a role as a metabolite. It is an alpha-amino acid, a member of imidazoles, an aromatic amino acid and a polar amino acid. It contains a 1H-imidazol-4-ylmethyl group. It is a conjugate base of a histidinium(1+). It is a conjugate acid of a histidinate(1-). | | General Description | Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation?deprotonation. | | Biochem/physiol Actions | Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)?poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment. |
| | POLY-L-HISTIDINE HYDROCHLORIDE MW Preparation Products And Raw materials |
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