| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:6-Methylsulfinylhexyl Isothiocyanate
CAS:4430-35-7
Package:500Mg,50Mg
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| | 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Basic information |
| | 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Chemical Properties |
| Boiling point | 385.9±25.0 °C(Predicted) | | density | 1.12±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator, under inert atmosphere | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | form | Oil | | color | Colourless to Pale Yellow | | LogP | 0.959 (est) |
| | 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Usage And Synthesis |
| Description | 6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities. It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 μM. It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 μM). 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 μM). In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson''s disease induced by 6-OHDA . 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model. | | Uses | 6-(Methylsulfinyl)hexyl isothiocyanate derived from Wasabia japonica was discovered as an inhibitor of glycogen synthase kinase-3β. | | Definition | ChEBI: 1-isothiocyanato-6-(methylsulfinyl)hexane is a sulfoxide. |
| | 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Preparation Products And Raw materials |
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