Company Name: |
Shanghai Tauto Biotech Co., Ltd.
|
Tel: |
021-51320588 |
Email: |
tauto@tautobiotech.com |
Products Intro: |
Product Name:Ferulenol CAS:6805-34-1 Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:AG-CN2-0011-M010
|
|
| FERULENOL Basic information |
Product Name: | FERULENOL | Synonyms: | FERULENOL;4-Hydroxy-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]-2H-1-benzopyran-2-one;4-Hydroxy-3-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-coumarin;2H-1-Benzopyran-2-one, 4-hydroxy-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-;FERULENOL USP/EP/BP | CAS: | 6805-34-1 | MF: | C24H30O3 | MW: | 366.49 | EINECS: | | Product Categories: | | Mol File: | 6805-34-1.mol | |
| FERULENOL Chemical Properties |
Melting point | 55-56℃ | Boiling point | 525.3±50.0 °C(Predicted) | density | 1.070±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | Soluble in DMSO | pka | 4.50±1.00(Predicted) | form | Off-white solid. | color | White to off-white | LogP | 7.730 (est) |
| FERULENOL Usage And Synthesis |
Uses | Ferulenol is antibiotic useful against mycobacteria similar to taxol. | Biological Activity | ferulenol is a prenylated 4-hydroxycoumarin derivative from ferula communis var. genuine with haemorrhagic action [1]. it has been demonstrated that ferulenol exihibits potent antimycobacterial activity [2]. | in vitro | ferulenol stimulated tubulin polymerization in the absence of gtp, with a less extensive polymerization profile at 100 pm concentration. ferulenol decreased radiolabeled colchicine bound by tubulin in a dose-dependent manner. ferulenol altered the normal nuclear morphology of mcf-7 cells. treatment with ferulenol (100 nm and 1 μm) for 24h induced a dose-dependent reduction of cell viability [3] | in vivo | in albino mice, the acute ld50s of ferulenol by single po or ip were 2,100 and 319 mg/kg bw, respectively. three days after ferulenol administration, dosed animals showed hypoprothrombinemia with internal and external hemorrhages. male mice were more sensitive to intoxication than females [4]. | storage | +4°C | references | [1] lamnaouer d, bodo b, martin m t, et al. ferulenol and ω-hydroxyferulenol, toxic coumarins from ferula communis var. genuina[j]. phytochemistry, 1987, 26(6): 1613-1615. [2] e. mamoci, i. cavoski, v. simone, et al. chemical composition and in vitro activity of plant extracts from ferula communis and dittrichia viscosa against postharvest fungi. molecules 16(3), 2609-2625 (2011). [3] bocca c, gabriel l, bozzo f, et al. microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol[j]. planta medica, 2002, 68(12): 1135-1137. [4] fraigui o, lamnaouer d, faouzi m y. acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from ferula communis l[j]. veterinary and human toxicology, 2002, 44(1): 5-7. |
| FERULENOL Preparation Products And Raw materials |
|