| Company Name: |
Tianjin Zhongtian Xinchuang Technology Co., Ltd. Gold
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| Tel: |
13312191509 |
| Email: |
1932163312@qq.com |
| Products Intro: |
Product Name:1-(2-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea
CAS:57460-41-0
Purity:>96% Package:250mg;500mg;1g;5g
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:rac-Talinolol
CAS:57460-41-0
Package:50Mg,5Mg
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| | Talinolol Basic information |
| Product Name: | Talinolol | | Synonyms: | 1-(3-(3-Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol;1-(4-(Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol;1-(4-Cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane;Cordanum;Racemic talinolol;rac-Talinolol
;1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea;1-(4-(3-(tert-butylaMino)-2-hydroxypropoxy)phenyl)-3-cyclohexylu | | CAS: | 57460-41-0 | | MF: | C20H33N3O3 | | MW: | 363.49 | | EINECS: | | | Product Categories: | Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 57460-41-0.mol |  |
| | Talinolol Chemical Properties |
| Melting point | 160-162°C | | Boiling point | 520.0±50.0 °C(Predicted) | | density | 1.11±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 13.82±0.20(Predicted) | | color | White to Pale Pink |
| HazardClass | IRRITANT | | Toxicity | LD50 in rats, mice (mg/kg): 1180, 593 orally; 54.3, 74.7 i.p.; 29.7, 25.0 i.v. (Femmer) |
| | Talinolol Usage And Synthesis |
| Description | (±)-Talinolol is a β1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. By blocking β1-adrenergic receptors, talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity. Because its metabolism in human liver microsomes is well understood, (±)-talinolol is useful for examining the activity of the drug-transporting MDR1 gene product P-glycoprotein. | | Chemical Properties | Off-White to Pale Pink Solid | | Uses | Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic. | | Definition | ChEBI: Talinolol is a member of ureas. | | references | [1] abmann i. the actions of talinolol, a β1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction[j]. current medical research and opinion, 2008, 13(6): 325-342.
[2] trausch b, oertel r, richter k, et al. disposition and bioavailability of the β1‐adrenoceptor antagonist talinolol in man[j]. biopharmaceutics & drug disposition, 1995, 16(5): 403-414. |
| | Talinolol Preparation Products And Raw materials |
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