(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione Suppliers list
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Product Name:(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(diMethyl)silyl]oxy}-5,5,7,9,13-pentaMethyl-16-[(E)-1-Methyl-2-(2-Methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione CAS:189453-35-8 Package:0.1Mg,1Mg
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Product Name:(4S,7R,8S,9S,13Z,16S)-4,8-BIS-([TERT-BUTYL(DIMETHYL)SILYL]OXY)-5,5,7,9,13-PENTAMETHYL-16-[(E)-1-METHYL-2-(2-METHYL-1,3-THIAZOL-4-YL)ETHENYL]OXOCYCLOHEXADEC-13-ENE-2,6-DIONE CAS:189453-35-8 Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Chemsky(shanghai)International Co.,Ltd.
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Product Name:(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(diMethyl)silyl]oxy}-5,5,7,9,13-pentaMethyl-16-[(E)-1-Methyl-2-(2-Methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione CAS:189453-35-8 Purity:98%
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S.Z. PhyStandard Bio-Tech. Co., Ltd.
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Product Name:(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(diMethyl)silyl]oxy}-5,5,7,9,13-pentaMethyl-16-[(E)-1-Methyl-2-(2-Methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione CAS:189453-35-8 Package:Mg Remarks:TRC
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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Product Name:(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(diMethyl)silyl]oxy}-5,5,7,9,13-pentaMethyl-16-[(E)-1-Methyl-2-(2-Methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione CAS:189453-35-8
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| (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione Basic information |
Product Name: | (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione | Synonyms: | (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione;[4S-[4R*,7S*,8R*,9R*,13Z,16R*(E)]]-4,8-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-;Oxacyclohexadec-13-ene-2,6-dione, 4,8-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (4S,7R,8S,9S,13Z,16S)-;Paclitaxel Impurity 73;(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[Tert-Butyl(Dimethyl)Silyl]Oxy}-5,5,7,9,13-Pentamethyl-16-[(E)-1-Methyl-2-(2-Methyl-1,3-Thiazol-4-Yl)Ethenyl]Oxcyclohexadec-13-Ene-2,6-Dione | CAS: | 189453-35-8 | MF: | C39H69NO5SSi2 | MW: | 720.2 | EINECS: | | Product Categories: | Chiral Reagents | Mol File: | 189453-35-8.mol | |
| (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione Chemical Properties |
Boiling point | 698.1±55.0 °C(Predicted) | density | 1.01±0.1 g/cm3(Predicted) | solubility | Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene | form | Foam | pka | 2.56±0.10(Predicted) | color | White |
| (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione Usage And Synthesis |
Chemical Properties | White Foam | Uses | An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
| (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione Preparation Products And Raw materials |
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