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Product Name:4-AMino-6-chloro-1-β-D-ribofuranosyliMidazo[4,5-c]pyridine CAS:40656-71-1 Package:50Mg,5Mg
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4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine manufacturers
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| 4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine Basic information |
Product Name: | 4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine | Synonyms: | 4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine;6-Amino-2-chloro-9-(b-D-ribofuranosyl)purine;2-chloro-3-Deazaadenosine;6-Chloro-1-β-D-ribofuranosyl-1H-iMidazo[4,5-c]pyridin-4-aMine;NSC 158900;(2R,3R,4S,5R)-2-(4-amino-6-chloro-1H-imidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;(2R,4R,5R)-2-(4-amino-6-chloroimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol;1H-Imidazo[4,5-c]pyridin-4-amine, 6-chloro-1-β-D-ribofuranosyl- | CAS: | 40656-71-1 | MF: | C11H13ClN4O4 | MW: | 300.7 | EINECS: | | Product Categories: | Nucleotides, Bases & Related Reagents;Bases & Related Reagents;Nucleotides | Mol File: | 40656-71-1.mol | |
| 4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine Chemical Properties |
Melting point | 223-225°C | Boiling point | 694.6±65.0 °C(Predicted) | density | 2.02±0.1 g/cm3(Predicted) | storage temp. | Refrigerator | solubility | DMSO, Methanol | form | Solid | pka | 13.18±0.70(Predicted) | color | Off-White to Beige |
| 4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine Usage And Synthesis |
Chemical Properties | Off-White Solid | Uses | Adenosine analog | Biological Activity | 2-chloro-3-deazaadenosine, a stable analog of adenosine, is an agonist for adenosine receptors [1].adenosine receptors are members of g-protein-coupled receptors (gpcrs). extracellular adenosine acts as a local modulator with a generally cytoprotective function in the body. extracellular adenosine has been implicated in increasing the ratio of oxygen supply to demand, protecting against ischaemic damage by cell conditioning, triggering anti-inflammatory responses and the promotion of angiogenesis [2]. | in vitro | the ki values of 2-chloro-3-deazaadenosine for a1, a2a, a2b, and a3 receptors were 0.3, 0.08, 25.5, and 1.9 μm, respectively [1]. 2-chloroadenosine (25 μm) increased activity of platelet adenylate cyclase to about 150–160% of the control value. higher concentrations of 2-chloroadenosine showed less effect above 100 μm [3]. | in vivo | in the rat with delayed ischaemic damage, iterative focal injections of 2-chloroadenosine protected against selective hippocampal ca1 loss [4]. | references | [1] linden j, thai t, figler h, et al. characterization of human a2b adenosine receptors: radioligand binding, western blotting, and coupling to gqin human embryonic kidney 293 cells and hmc-1 mast cells[j]. molecular pharmacology, 1999, 56(4): 705-713. [2] jacobson k a, gao z g. adenosine receptors as therapeutic targets[j]. nature reviews drug discovery, 2006, 5(3): 247-264. [3] haslam r j, lynham j a. activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine[j]. life sciences, 1972, 11(23): 1143-1154. [4] evans m c, swan j h, meldrum b s. an adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus[j]. neuroscience letters, 1987, 83(3): 287-292. |
| 4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine Preparation Products And Raw materials |
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