- 2-Aminothiazole
-
- $0.00 / 25Kg/Drum
-
2024-05-31
- CAS:96-50-4
- Min. Order: 1ASSAYS
- Purity: 99%
- Supply Ability: 200mt/year
- 2-Aminothiazole
-
- $58.00/ kg
-
2024-05-22
- CAS:96-50-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000kg/week
- 2-Aminothiazole
-
- $18.00 / 1kg
-
2024-04-10
- CAS:96-50-4
- Min. Order: 1kg
- Purity: 99.9%
- Supply Ability: 50000tons
|
| | 2-Aminothiazole Basic information |
| | 2-Aminothiazole Chemical Properties |
| Melting point | 91-93 °C (lit.) | | Boiling point | 117 °C (15.002 mmHg) | | density | 1.241 (estimate) | | vapor pressure | <1 hPa (20 °C) | | refractive index | 1.5300 (estimate) | | Fp | 117°C/15mm | | storage temp. | Store below +30°C. | | solubility | 1 M HCl: soluble50mg/mL, clear (dark yellow-brown) | | pka | 5.36(at 20℃) | | form | Crystalline Powder, Grains, Lumps or Flakes | | color | Brown | | PH | 9.6 (100g/l, H2O, 20℃) | | Water Solubility | 100 g/L (20 ºC) | | Merck | 14,479 | | BRN | 105738 | | InChIKey | RAIPHJJURHTUIC-UHFFFAOYSA-N | | LogP | 0.380 | | CAS DataBase Reference | 96-50-4(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Aminothiazole(96-50-4) | | EPA Substance Registry System | 2-Aminothiazole (96-50-4) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36-36/37-20/21/22 | | Safety Statements | 26-36/37-39-36 | | WGK Germany | 3 | | RTECS | XJ2100000 | | F | 8-9 | | Autoignition Temperature | 600 °C | | Hazard Note | Irritant | | TSCA | Yes | | HS Code | 29341000 | | Toxicity | LD50 orally in Rabbit: 480 mg/kg |
| | 2-Aminothiazole Usage And Synthesis |
| Chemical Properties | brown crystalline powder, grains, lumps or flakes | | Uses | Usually used in the synthesis of 2-aminothiazole-modified silica gel，and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation. | | Uses | antithyroid agent | | Uses | 2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds. | | Definition | ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2. | | Synthesis Reference(s) | Journal of the American Chemical Society, 76, p. 693, 1954 DOI: 10.1021/ja01632a016 | | General Description | Light brown crystals or brown granular solid. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | 2-Aminothiazole reacts violently when nitrated with nitric or nitric-sulfuric acids. 2-Aminothiazole is also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. | | Fire Hazard | Flash point data for 2-Aminothiazole are not available; however, 2-Aminothiazole is probably combustible. | | Biochem/physiol Actions | 2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders. | | Safety Profile | Poison by ingestion andintraperitoneal routes. Mutation data reported.Spontaneous ignition occurs at 100°. Mixtures with nitricacid or nitric acid + sulfuric acid explode on heating.Incompatible with HNO3 and H2SO4. When heated todecomposition it emi | | Purification Methods | It crystallises from pet ether (b 100-120o), or EtOH. [Beilstein 27 III/IV 4574.] |
| | 2-Aminothiazole Preparation Products And Raw materials |
| Raw materials | Thiourea-->Chloroacetaldehyde | | Preparation Products | ethyl 2-(2-aminothiazol-5-ylthio)acetate-->BASIC RED 29-->2-Amino-5-nitrothiazole-->2-Amino-((1-carboxy-1-methyl ethoxy)imino)-4-thiazoleacetic acid-->3-(-Hydroxyphenethyl)-2-imino thiazolidine-->2-Amino-5-bromothiazole monohydrobromide-->2-CHLORO-5-NITROTHIAZOLE-->1,3-Thiazole-2-carbaldehyde-->Cationic Violet 3BL-->2-Amino-5-bromothiazole-->Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid-->Nitazoxanide Impurity-->Oxazole-2-amine-->CHEMBRDG-BB 4024592-->4,5,6,7-tetrachloro-2-(1,3-thiazol-2-yl)isoindole-1,3-dione-->2,2,2-trichloro-N-1,3-thiazol-2-ylacetamide-->2-Pyridinamine, N-(5-bromo-2-thiazolyl)--->1H-Benz[de]isoquinoline-1,3(2H)-dione,2-(2-thiazolyl)- |
|