| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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| Products Intro: |
Product Name:Monoclonal Anti-Tyrosine Hydroxylase antibody produced in mouse
Purity:clone TH-2, ascites fluid Package:.2ML Remarks:T1299-.2ML
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| | ANTI-TYROSINE HYDROXYLASE Basic information |
| Product Name: | ANTI-TYROSINE HYDROXYLASE | | Synonyms: | ANTI-TYROSINE HYDROXYLASE;ANTI-TYROSINE HYDROXYLASE MOUSE MAB;ANTI-TYROSINE HYDROXYLASE RABBIT PAB;ANTI-TYROSINE HYDROXYLASE, RAT;ANTI-TYROSINE HYDROXYLASE, RAT (MOUSE);ANTI-TYROSINE HYDROXYLASE, RAT (RABBIT);ANTI-TYROSINE HYDROXYLASE, RAT (SHEEP);ANTI-TYROSINE HYDROXYLASE SHEEP PAB | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-TYROSINE HYDROXYLASE Structure]() |
| | ANTI-TYROSINE HYDROXYLASE Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous glycerol solution |
| | ANTI-TYROSINE HYDROXYLASE Usage And Synthesis |
| Uses | Monoclonal Anti-Tyrosine Hydroxylase antibody produced in mouse has also been used in
- western blotting
- immunofluorescence labelling
- immunohistochemical staining
- enzyme linked immunosorbent assay (ELISA)
- dot blot
- immunoprecipitation
- immunocytochemistry
| | General Description | Monoclonal Anti-Tyrosine Hydroxylase (mouse IgG1 isotype) is derived from the TH-16 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Tyrosine hydroxylase (TH) exists in four isoforms in humans. They are are TH-1 (M.W. 55,600), TH-2 (4 additional amino acids; M.W. 56,000), TH-3, (27 additional amino acids; M.W. 58,100), and TH-4 (4 plus 27 additional amino acids; 58,500). Only humans express all four isoforms; all other anthropoids express only the TH-1 and TH-2 isoforms. | | Biochem/physiol Actions | Tyrosine hydroxylase (TH) catalyzes the first rate limiting step in the biosynthesis of catecholamine neurotransmitter i.e. the conversion of L-tyrosine to L-dopa. Inhibition of TH by L-phenylalanine, might play a crucial role in phenylketonuria and block the synthesis of norepinephrine. Activity of TH can be regulated by phosphorylation. Decreased expression of TH is associated with various neuropsychiatric diseases such as schizophrenia and Parkinson′s disease (PD). |
| | ANTI-TYROSINE HYDROXYLASE Preparation Products And Raw materials |
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