| Company Name: |
MedBioPharmaceutical Technology Inc
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021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:THIENYLDECYL ISOTHIOCYANATE
CAS:288323-41-1
Purity:98% Package:5mg (solution); 10mg (solution) Remarks:Medbio
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| Company Name: |
Shaanxi Didu New Material Co., Ltd
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| Tel: |
029-63373950 15353716720 |
| Email: |
1052@dideu.com |
| Products Intro: |
Product Name:THIENYLDECYL ISOTHIOCYANATE
CAS:288323-41-1
Purity:98% Package:25KG
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:Thienyldecyl isothiocyanate
CAS:288323-41-1
Purity:98% Package:1mg;5mg;10mg
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| | THIENYLDECYL ISOTHIOCYANATE Basic information |
| | THIENYLDECYL ISOTHIOCYANATE Chemical Properties |
| Boiling point | 399.5±15.0 °C(Predicted) | | density | 1.02±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤30mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide | | form | solution in ethanol. |
| | THIENYLDECYL ISOTHIOCYANATE Usage And Synthesis |
| Biological Activity | thienyldecyl isothiocyanate is a cytochrome p450 inhibitor [1].the human cytochrome p450 (cyp), a cellular chromophore, has been implicated in metabolism of drugs, arachidonic acid, foreign chemicals, and eicosanoids; steroid synthesis and metabolism; vitamin d3 synthesis and metabolism; cholesterol metabolism and bile-acid biosynthesis; retinoic acid hydroxylation. until now, there are more than 270 different cyp gene families have been identified, with 18 recorded in mammals. it has been repoted that cytochrome p450 is now understood to include a myriad of enzymic reactions implicated in important life processes. mutations in many cyp genes result in inborn errors of metabolism and contribute to many clinically relevant diseases [2].thienyldecyl isothiocyanate was an analog of thienylbutyl isothiocyanate. thienyldecyl isothiocyanate showed antiproliferative activity against cancer cells presumably that, like many isothiocyanates. thienyldecyl isothiocyanate functioned by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome p450, and/or by induction of phase ii detoxifying enzymes [1]. | | references | [1] yu r, mandlekar s, harvey k j, et al. chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity[j]. cancer research, 1998, 58(3): 402-408.
[2] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162. |
| | THIENYLDECYL ISOTHIOCYANATE Preparation Products And Raw materials |
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