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ANISOMYCIN

ANISOMYCIN Suppliers list
Company Name: Apeloa production Co.,Limited
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Products Intro: Product Name:Anisomycin
CAS:22862-76-6
Purity:0.98 Package:1g;1.00;USD
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-(0)57185586718 +86-13336195806
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Products Intro: Product Name:ANISOMYCIN
CAS:22862-76-6
Purity:98% Min. Package:1G;1KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:ANISOMYCIN
CAS:22862-76-6
Purity:99% Package:25KG;5KG;1KG
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
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Products Intro: Product Name:ANISOMYCIN
CAS:22862-76-6
Purity:95%-99% Package:1kg;1USD
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Anisomycin
CAS:22862-76-6
Purity:>=98% Package:500mg Remarks:BOC Sciences also provides custom synthesis services for Anisomycin.

ANISOMYCIN manufacturers

  • Anisomycin
  • Anisomycin pictures
  • $1.00 / 1g
  • 2024-10-23
  • CAS:22862-76-6
  • Min. Order: 1g
  • Purity: 0.98
  • Supply Ability: 1000
  • ANISOMYCIN
  • ANISOMYCIN pictures
  • $8000.00 / 1KG
  • 2021-11-27
  • CAS:22862-76-6
  • Min. Order: 100g
  • Purity: 99.99%
  • Supply Ability: 5ton/Month
  • ANISOMYCIN
  • ANISOMYCIN pictures
  • $1.00 / 1kg
  • 2019-07-06
  • CAS:22862-76-6
  • Min. Order: 1kg
  • Purity: 95%-99%
  • Supply Ability: 100kg
ANISOMYCIN Basic information
Product Name:ANISOMYCIN
Synonyms:(2R,3S,4S)-2-(4-METHOXYBENZYL)-3,4-PYRROLIDINEDOIL-3-ACETATE;(2R,3S,4S)-2-[(4-METHOXYPHENYL)METHYL]-3,4-PYRROLIDINEDIOL 3-ACETATE;2-(P-METHOXYBENZYL)-3,4-PYRROLIDINEDIOL-3-ACETATE;2-P-METHOXYPHENYLMETHYL-3-ACETOXY-4-HYDROXYPYRROLIDINE;1,4,5-trideoxy-1,4-imino-5-(p-methoxyphenyl)-D-xylo-pentitol 3-acetate;ANISOMYCIN FROM STREPTOMYCES GRISEOLUS;3,4-Pyrrolidinediol, 2-(4-methoxyphenyl)methyl-, 3-acetate, (2R,3S,4S)-;(2R,3S,4S)-2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate
CAS:22862-76-6
MF:C14H19NO4
MW:265.3
EINECS:245-269-7
Product Categories:antibiotic;Antibiotics;Protein Kinase
Mol File:22862-76-6.mol
ANISOMYCIN Structure
ANISOMYCIN Chemical Properties
Melting point 140-141 C
Boiling point 408.52°C (rough estimate)
alpha D23 -30° (methanol)
density 1.1356 (rough estimate)
refractive index 1.5230 (estimate)
Fp 87℃
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility methanol: 20 mg/mL, clear, colorless to faintly yellow
form solid
pka7.9(at 25℃)
color white
Water Solubility Soluble in water at 2 mg/ml, in DMSO at 20mg/ml, and in methanol at 20mg/ml
λmax283nm(EtOH)(lit.)
Merck 14,670
BRN 20705
Stability:Stable. Incompatible with strong oxidizing agents.
InChIKeyYKJYKKNCCRKFSL-RDBSUJKOSA-N
Safety Information
Hazard Codes T,Xn
Risk Statements 25-36/37/38-20/21/22
Safety Statements 45-36-26
RIDADR UN 3462 6.1/PG 3
WGK Germany 3
RTECS BZ9800000
3-10
HazardClass 6.1(b)
PackingGroup III
HS Code 29419090
ToxicityLD50 orl-rat: 72 mg/kg ANTCAO 5,490,55
MSDS Information
ProviderLanguage
SigmaAldrich English
ANISOMYCIN Usage And Synthesis
DescriptionAnisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable.
Chemical PropertiesCrystalline
UsesIt is applied as an antiparasitic agent and antineoplastic agent. It acts as a protein synthesis inhibitor (blocks translation), potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. It also scts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD). Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK).
UsesAnisomycin is a phenylmethylenepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin is an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells.
DefinitionChEBI: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Biological ActivityProtein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
Biochem/physiol ActionsAntibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.
Safety ProfilePoison by ingestion,intraperitoneal, subcutaneous, and intravenous routes.When heated to decomposition it emits toxic fumes ofNOx.
storage+4°C
References1) Hazzalin?et al. (1998),?Anisomycin Selectively Desensitizes Signalling Components Involved in Stress Kinase Activation and fos and jun Induction; Mol. Cell. Bio.,?8?1844 2) Mawji?et al. (2007),?A Chemical Screen Identifies Anisomycin as an Anoikis Sensitizer That Functions by Decreasing FLIP Protein Synthesis; Cancer Res.,?67?8307
ANISOMYCIN Preparation Products And Raw materials
Tag:ANISOMYCIN(22862-76-6) Related Product Information
Ciprofloxacin hydrochloride ANISOMYCIN (R)-3-METHOXYPYRROLIDINE (3S,4S)-Pyrrolidine-3,4-diol 3-PHENYLPROPYL ACETATE 4-(4-METHOXYPHENYL)-1-BUTANOL 4-PHENYL-2-BUTYL ACETATE 3-METHOXYPYRROLIDINE 3-PHENYLPROPYL FORMATE 3-ETHOXYPYRROLIDINE 1-(4-METHOXY-PHENYL)-2-BUTANAMINE 2-BENZYLPYRROLIDINE Benzenepentanamine NIH 3T3 - ANISOMYCIN CONTROL LYSATE HELA - ANISOMYCIN CONTROL LYSATE 50 MG ANISOMYCIN FROM STREPTOMYCESGRISEOLUS NIH 3T3 AND ANISOMYCIN LYSATE HELA AND ANISOMYCIN LYSATE