3-Morpholinosydnonimine hydrochloride

3-Morpholinosydnonimine hydrochloride Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
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Products Intro: Product Name:3-Morpholinosydnonimine hydrochloride
CAS:16142-27-1
Purity:0.99 Package:5KG;1KG
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Products Intro: Product Name:(3-Morpholino-1,2,3-oxadiazol-3-ium-5-yl)amide hydrochloride
CAS:16142-27-1
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Products Intro: Product Name:3-morpholinosydnonimine hydrochloride
CAS:16142-27-1
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Products Intro: Product Name:3-Morpholinosydnonimine hydrochloride
CAS:16142-27-1
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Products Intro: Product Name:Linsidomine hydrochloride
CAS:16142-27-1
Purity:99.81% Package:5mg;64USD|10mg;97USD|25mg;176USD Remarks:REAGENT;FOR LABORATORY USE ONLY

3-Morpholinosydnonimine hydrochloride manufacturers

3-Morpholinosydnonimine hydrochloride Basic information
Product Name:3-Morpholinosydnonimine hydrochloride
Synonyms:3-(4-MORPHOLINYL)-SYDNONE IMINE HYDROCHLORIDE;3-MORPHOLINOSYDNOIMINE HCL;3-MORPHOLINOSYDNOIMINE HYDROCHLORIDE;3-MORPHOLINOSYDNONIMINE CHLORIDE;3-MORPHOLINOSYDNONIMINE HCL;3-MORPHOLINOSYDNONIMINE HYDROCHLORIDE;3-MORPHOLINOSYDNONIMIN HYDROCHLORIDE;5-AMINO-3-MORPHOLINYL-1,2,3-OXADIAZOLIUM CHLORIDE
CAS:16142-27-1
MF:C6H11ClN4O2
MW:206.63
EINECS:605-254-1
Product Categories:Various Metabolites and Impurities;Metabolites & Impurities;Nitric Oxide Reagents
Mol File:16142-27-1.mol
3-Morpholinosydnonimine hydrochloride Structure
3-Morpholinosydnonimine hydrochloride Chemical Properties
Melting point 186 °C
density 1.303 at 20℃
storage temp. -20°C
solubility Soluble in DMSO (up to 35 mg/ml) or in Water (up to 65 mg/ml)
form White solid
color White
Water Solubility soluble
Stability:Stable for 1 year from date of purchase as supplied. Solutions must be prepared fresh and cannot be stored.
LogP-6.28 at 25℃
CAS DataBase Reference16142-27-1(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 3
RTECS WU7687800
HS Code 29349990
MSDS Information
ProviderLanguage
SIN-1 hydrochloride English
ACROS English
3-Morpholinosydnonimine hydrochloride Usage And Synthesis
DescriptionAs the active metabolite of molsidomine, SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions.
Chemical PropertiesWhite Crystalline Solid
Uses3-Morpholinosydnonimine hydrochloride has been used:
  • as a peroxynitrite donor standard to study the accumulation of peroxynitrite?in?Arabidopsis thaliana
  • to study its effects on nitrosative stress in human brain vascular pericytes and human embryonic kidney cells
  • as a ROS to study its effects on mouse embryonic fibroblasts

UsesSIN-1 is a metabolite of the vasodilator molsidomine and is considered to be a peroxynitrite releasing compound
Uses3-Morpholinosydnonimine hydrochloride is a metabolite of the vasodilator Molsidomine (M488002) and is considered to be a peroxynitrite releasing compound. Molsidomine Impurity A.
IndicationsLinsidomine (SIN-1) is an active metabolite of the antianginal drug molsidomine. Its mechanism of action upon the corpus cavernosum involves the release of nitric oxide. Injected intracavernosally it can produce penile erections, but its clinical usefulness has not been fully established.
Biological ActivityThis compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.
Biochem/physiol Actions3-Morpholinosydnonimine participates in the inhibition of cysteine proteases.
storageStore at +4°C
References1) Nishikawa?et al.?(1982)?Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites;?J. Pharmacol. Exp. Ther.?220?183 2) Hogg?et al.?(1992)?Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide; Biochem. J.?281?419 3) Kirsch?et al.?(1998)?Hydrogen peroxide formation by reaction of peroxynitrite with HEPES and related tertiary amines. Implications for a general mechanism.; J. Biol. Chem.?273?12716 4) Priora?et al.?(2011)?In vitro inhibition of human and rat platelets by NO donors nitrosoglutathione sodium nitroprusside and SIN-1 through activation of cGMP independent pathways; Pharmacol. Res.?64?289 5) Ren?et al.?(2017)?Identification of a New Function of Cardiovascular Disease Drug 3-Morpholinosydnonimine Hydrochloride as an Amyloid-β Aggregation Inhibitor;?ACS Omega.?2?243
3-Morpholinosydnonimine hydrochloride Preparation Products And Raw materials
Raw materialsPOTASSIUM CYANIDE-->N-Aminomorpholine
Preparation ProductsCiclosidomine
Tag:3-Morpholinosydnonimine hydrochloride(16142-27-1) Related Product Information
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