ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Quinoline compounds >6-Methylisoquinoline

6-Methylisoquinoline

6-Methylisoquinoline Suppliers list
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:6-Methylisoquinoline
CAS:42398-73-2
Purity:0.99 Package:5KG;1KG
Company Name: Chengdu Feibo Pharm Technology Co., Ltd
Tel: 15982321820
Email: abby@arkpharm.com
Products Intro: Product Name:6-methylisoquinoline
CAS:42398-73-2
Purity:97% Package:25g;100g;250g
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:6-Methylisoquinoline
CAS:42398-73-2
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-14919
Company Name: Wuhan Chemwish Technology Co., Ltd
Tel: 027-67849912
Email: sales@chemwish.com
Products Intro: Product Name:6-Methylisoquinoline
CAS:42398-73-2
Purity:0.98 Package:1g;5g;25g;1756g
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:6-methylisoquinoline
CAS:42398-73-2
Purity:99% Package:1mt

6-Methylisoquinoline manufacturers

  • 6-Methylisoquinoline
  • 6-Methylisoquinoline  pictures
  • $1.10 / 1g
  • 2022-03-07
  • CAS:42398-73-2
  • Min. Order: 1g
  • Purity: 99.00%
  • Supply Ability: 100 Tons
  • 6-Methylisoquinoline
  • 6-Methylisoquinoline pictures
  • $3.00 / 1KG
  • 2020-01-19
  • CAS:42398-73-2
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1kg,5kg,50kg
  • 6-Methylisoquinoline
  • 6-Methylisoquinoline pictures
  • $1.00 / 1KG
  • 2020-01-15
  • CAS:5340-45-5
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1KG, 5KG, 50KG
6-Methylisoquinoline Basic information
Product Name:6-Methylisoquinoline
Synonyms:6-Methylisoquinoline 98%;6-Methylisoquinoline;Isoquinoline, 6-methyl-;6-Methylisoquinoline ,98%;3,4,4-trimethylpentan-2-one;6-Methylisoquinoline ISO 9001:2015 REACH
CAS:42398-73-2
MF:C10H9N
MW:143.19
EINECS:255-794-3
Product Categories:Quinoline&Isoquinoline;Isoquinoline Derivertives;blocks;Heterocycles;Quinolines;Heterocyclic Series
Mol File:42398-73-2.mol
6-Methylisoquinoline Structure
6-Methylisoquinoline Chemical Properties
Melting point 85.5°C
Boiling point 246.29°C (estimate)
density 1.0584 (estimate)
refractive index 1.6103 (estimate)
pka5.85±0.10(Predicted)
form solid
color Beige
CAS DataBase Reference42398-73-2(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36
Safety Statements 26-24/25
Hazard Note Irritant
HS Code 29334900
MSDS Information
6-Methylisoquinoline Usage And Synthesis
Chemical PropertiesLight beige powder
Uses6-Methylisoquinoline (cas# 42398-73-2) is a useful reagent for the green preparation of polyfluoroarylated heterocyclic compounds.
PreparationA benzene solution (50 ml, CAUTION) of equimolar amounts of p-tolualdehyde (8.4 g, 0.07 mol) and aminoacetaldehyde dimethyl acetal (7.35 g, 0.07 mol) is refluxed overnight into a Dean and Stark trap. The solution is evaporated in vacuo and then twice evaporated again with added benzene and the viscous oil dissolved in dry tetrahydrofuran. This solution is cooled to - 10 °C and 1 equivalent of ethyl chloroformate (7. 1 ml, 0.07 mol) is added with rapid stirring and the mixture stirred for a further 5 minutes. The cooling bath is removed and 1.2 equivalents of trimethyl phosphite ( 10.5 ml, 0.09 mol) is added with stirring. The solution is stirred at room temperature for 1 5 hours and then evaporated t o an oil. The oil is then re-evaporated twice with added toluene to remove traces of trimethyl phosphite. The oil is dissolved in dry dichloromethane, 6 equivalents of titanium(1v) chloride (50 ml, 0.45 mol) is added and the solution refluxed for 36 hours under a drying tube. The cooled solution is shaken with 1 equivalent of aqueous sodium hydroxide solution to neutrality, whereupon titanium(1v) oxide precipitates as a white solid. The filtered organic layer is extracted with 3 M hydrochloric acid, and the extract is washed with dichloromethane, basified strongly with aqueous alkali, and extracted with dichloromethane. This organic extract is dried over anhydrous sodium sulphate and evaporated to afford 6-methylisoquinoline (yield 7 1 %, m.p. 88 °C).
Synthesis Reference(s)The Journal of Organic Chemistry, 48, p. 3344, 1983 DOI: 10.1021/jo00167a043
Tag:6-Methylisoquinoline(42398-73-2) Related Product Information
1,2,3,4-TETRAHYDROISOQUINOLINE N,N-Dimethylformamide Carboxymethyl cellulose Sodium carboxymethyl cellulose 2,6-Dimethylphenol 2,6-Lutidine Isoquinoline 6-methylisoquinolin-3-amine 3-Methylisoquinoline methylisoquinolin (-)-2-[METHYLAMINO]-1-PHENYLPROPANE 6-isoquinolinecarboxylic acid 6-Isoquinolinecarboxaldehyde (9CI) Cisatracurium besylate Atracurium besylate 7-Methyl isoquinoline 6-(bromomethyl)isoquinoline 1-ACETAMIDO-4-CYANO-3-METHYLISOQUINOLINE