| Company Name: |
Harika Drugs Pvt Ltd
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| Tel: |
+91-4023814863 +91-4023814863 |
| Email: |
info@harikadrugs.com |
| Products Intro: |
Product Name:Oxomemazine hydrochloride
CAS:4784-40-1
Purity:99% Package:1 kg,5 kg, 10 kg,25kg and 1 MT
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| Company Name: |
Ralington Pharma
|
| Tel: |
+91-7948911722 +91-9687771722 |
| Email: |
info@ralingtonpharma.com |
| Products Intro: |
Product Name:Oxomemazine hydrochloride
CAS:4784-40-1
Purity:98% Package:1 kg,5 kg, 10 kg,25kg and 1 MT
|
N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride manufacturers
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| | N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride Basic information |
| Product Name: | N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride | | Synonyms: | Oxomemazine hydrochloride;Oxomemazine·hydrochloric acid;Ao Suoma hydrochloride;10-(3-(dimethylamino)-2-methylpropyl)-10H-phenothiazine 5,5-dioxide hydrochloride;N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride;N,N,β-Trimethyl-[10H]-phenothiazine-10-propanamine 5,5-dioxide hydrochloride | | CAS: | 4784-40-1 | | MF: | C18H23ClN2O2S | | MW: | 366.9 | | EINECS: | 225-330-4 | | Product Categories: | | | Mol File: | 4784-40-1.mol |  |
| | N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride Chemical Properties |
| | N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride Usage And Synthesis |
| Originator | Doxergan,Specia,France,1964 | | Manufacturing Process | Phenothiazine is reacted with 3-dimethylamino-2-methylpropyl chloride in the presence of sodium amide to give 3-(10-phenthiazinyl)-2-methyl-1dimethylaminopropane. 11.9 g of of this intermediate is dissolved with agitation in glacial acetic acid (120 cc). Pure sulfuric acid (d = 1.83; 0.5 cc) is added and a mixture of glacial acetic acid (10 cc) and hydrogen peroxide (8.5 cc of a solution containing 38 g of hydrogen peroxide in 100 cc) is then run in over 20 minutes. The temperature rises from 25°C to 35°C and is then kept at 60°C for 18 hours. The mixture is cooled and water (150 cc) is added and, with cooling, aqueous sodium hydroxide (d = 1.33; 220 cc). The resulting
mixture is extracted with ethyl acetate (3 x 100 cc), the solvent is evaporated on a water bath and the residue is recrystallized from heptane (150 cc). 3(9,9-dioxy-10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (78 g) is obtained, MP 115°C.
The corresponding hydrochloride prepared in ethyl acetate and recrystallized from a mixture of ethanol and isopropanol melts at 250°C. | | Therapeutic Function | Antihistaminic |
| | N,N,beta-trimethyl-10H-phenothiazine-10-propylamine 5,5-dioxide monohydrochloride Preparation Products And Raw materials |
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