Ethyl 5-bromothiophene-3-carboxylate manufacturers
|
| Ethyl 5-bromothiophene-3-carboxylate Basic information |
Product Name: | Ethyl 5-bromothiophene-3-carboxylate | Synonyms: | Ethyl 5-bromothiophene-3-carboxylate;5-BroMo-thiophene-3-carboxylic acid ethyl ester;5-Bromothiophene-3-carboxylic acid ethyl ester, >=98%;5-bromo-3-Thiophenecarboxylic acid ethyl ester;PI-35048 ethyl 5-bromothiophene-3-carboxylate;Ethyl 5-bromothiophene-3-carboxylate 97+%;3-Thiophenecarboxylic acid, 5-bromo-, ethyl ester;Ethyl 5-bromothiophene-4-carboxylate | CAS: | 170355-38-1 | MF: | C7H7BrO2S | MW: | 235.1 | EINECS: | | Product Categories: | | Mol File: | 170355-38-1.mol | |
| Ethyl 5-bromothiophene-3-carboxylate Chemical Properties |
Boiling point | 65-66 °C | density | 1.572±0.06 g/cm3(Predicted) | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | form | liquid | color | Colourless to yellow | InChI | InChI=1S/C7H7BrO2S/c1-2-10-7(9)5-3-6(8)11-4-5/h3-4H,2H2,1H3 | InChIKey | LUYMKCLOYODOEI-UHFFFAOYSA-N | SMILES | C1SC(Br)=CC=1C(OCC)=O |
| Ethyl 5-bromothiophene-3-carboxylate Usage And Synthesis |
Synthesis | 20 g (147 mmol) of aluminum chloride are added portion-wise to a solution of 10 g (67 mmol) of ethyl thiophene-3-carboxylate in 160 ml of dichloro-methane, cooled to 0oC. The reaction medium is warmed to room temperature, and a solution of 4 ml (73 mmol) of bromine in 10 ml of dichloromethane is added. After reaction for 50 minutes at room temperature, the reaction medium is poured into a water + ice mixture and extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered, and evaporated under vacuum. The residue obtained is purified by chromatography on a column of silica eluted with a 9/1 HEPTANE/ETHYL acetate mixture. 9 g (57percent) of ethyl 5-bromothiophene-3-carboxylate are obtained.
| Uses | Ethyl 5-bromothiophene-3-carboxylate is an important organic reagent that can be used as a building block for the synthesis of many organic compounds. After hydrolysis, it can synthesize 5-Bromothiophene-3-carboxylic acid. |
| Ethyl 5-bromothiophene-3-carboxylate Preparation Products And Raw materials |
|